February 2011
Pharmacokinetic drug interactions of phosphodiesterase-5 inhibitors mediated by cytochrome P450 3A4 isoform
Novel drugs for Erectile Dysfunction (ED) must be assessed for their interactions with other already approved medications that are processed through similar metabolic pathways. The cytochrome P450 enzyme family, in particular 3A4 isoform, is ubiquitously used to oxidize azole antifungals, erythromycin, and HIV protease inhibitors. Administering multiple medications using cytochrome P450 CYP3A4 (3A4) as a...
February 2011
Antibiotics sensitivity pattern of staphylococcus aureus from fomites in the Obafemi Awolowo University Teaching Hospital Complex (OAUTHC) Nigeria
This study determines the possible roles of cross contamination in the hospital environment. Two hundred swabs were obtained from doctors’ stethoscope diaphragm, cell phones of Health Care Workers (HCWS), patients’ bed linen, pillows and door knobs at the Obafemi Awolowo University Teaching Hospitals Complex, Ile-Ife, from September 2003 to September 2005 using sterile cotton-tipped applicators....
February 2011
In vitro and in vivo antitumor activity of some synthesized 4-(2-pyridyl)-3-Thiosemicarbazides derivatives
In search for potential antitumor drug candidates, a series of thiosemicarbazide derivatives were prepared via 4-(2-pyridyl)-3-thiosemicarbazide with phenyl isothiocyanate, benzoyl isothiocyanate, phenyl isocyanate and 4-pyridyl isothiocyanate. Effects of the synthesized compounds were tested using in vitro growth of a transplantable murine tumor cell line (Ehrlich Ascites Carcinoma) and in vivo-induced...
February 2011
Palm and Egusi melon oils lower serum and liver lipid profile and improve antioxidant activity in rats fed a high fat diet
Many studies have suggested that oils high in saturated fatty acids are responsible for the cholesterol-raising effect of saturated fat. The aim of this study was to compare the effect of palm oil (rich in saturated fatty acid) and egusi melon oil (rich in unsaturated fatty acids) on serum and liver lipids and their antioxidant status. Lipid profiles, malondialdehyde (MDA) levels and activities of glutathione...
February 2011
Long-term testicular toxicity caused by doxorubicin treatment during pre-pubertal phase
Doxorubicin is a potent drug widely used against different types of cancer and can cause damage to healthy tissues. Some studies have shown that this drug causes apoptosis of male germ cells. However, a detailed and long-term morphological study about the damages caused by doxorubicin administration to early prepubertal testis and to future fertility of the rat is missing. Male rats were treated at 15 days...
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