February 2017

Review of cardiac protein quality control and major degradation pathways

Protein quality control (PQC) senses and repairs misfolded and or unfolded proteins. However, if the repair fails, it degrades the terminally misfolded polypeptides through an intricate collaboration between molecular chaperones and targeted proteolysis. Proteolysis of damaged proteins is performed primarily by the ubiquitin-proteasome system (UPS). Macroautophagy (commonly known as autophagy) may also play a role in...

Author(s): Osalusi, B. S.