March 2009
Prostatic adenocarcinoma coexisting with schistosomiasis: A case report and review of literature
Adenocarcinoma of the prostate is the commonest form of cancer in men and the second leading cause of cancer death. Not much is known about the aetiology of prostatic cancer. We report a rare case of prostatic adenocarcinoma coexisting with schistosomiasis of the prostate, and review of literature. The association between schistosomiasis and cancer has been well documented in bladder cancer, implicating the...
March 2009
Update to risk factors for hepatocellular carcinoma
Hepatocellular carcinoma (HCC) became a prevalent disease in many populations worldwide. It initiates many economic problems in management modalities and leads to increasing mortality rates. Many trials are made all over the world to implement specific early markers for detection and prediction of the disease, hoping to set a more precise strategy for liver cancer prevention. Unfortunately, many economic, cultural and...
March 2009
Brief review of sarcoidosis of the thyroid gland
Sarcoidosis of the thyroid gland is rare. It is rarely reported in the medical literature. In this review article we go over various presentation of sarcoidosis of the thyroid gland, ways to diagnose it, and treatment options. Key words: Sarcoidosis, thyroid gland, hypothyroidism, Graves' disease
March 2009
Differential induction of LRP16 by liganded and unliganded estrogen receptor a in SKOV3 ovarian carcinoma cells
Previously, we investigated the induction effect of LRP16 expression by estrogen (E2) and established a feed-forward mechanism that activated ERa transactivation in estrogen-dependent epithelial cancer cells. LRP16 is required for ERa signaling transduction by functioning as an ERa coactivator. In this study, we demonstrated that LRP16 expression was up-regulated in E2-responsive BG-1 ovarian cancer...
March 2009
In situ distribution of hepatitis C virus (HCV) RNA in the liver: Relationship to histopathology and serum HCV-RNA levels
In situ hybridization (ISH) technique was applied to 60 liver biopsies obtained from Egyptian patients with chronic HCV hepatitis in an attempt to: assess the tissue localization of HCV RNA in the liver and to investigate its relationship to the liver pathology, serum level of alanine transaminase (ALT) and viral load in the serum. No similar studies have been reported from Egypt, which is an area of high HCV...
March 2009
Hepatoprotective and some haematological effects of Allium sativum and vitamin C in lead-exposed Wistar rats
The hepatoprotective and some haematological effects of Allium sativum (Garlic) and vitamin C were studied on experimental rats that were exposed to lead (Pb) for one week. Twenty – four female Wistar rats were divided into four groups of six rats per group. Rats in group A were kept as the control. Rats in groups B, C and D were exposed to 100 µmol/kg body weight of lead acetate intraperitoneally...
March 2009
Multi-drug resistant Staphylococcus aureus in clinical cases in Ile-Ife, Southwest Nigeria
A study to investigate the susceptibility pattern of Staphylococcus aureus to conventional antibiotics being frequently prescribed in Ile-Ife, South Western Nigeria was carried out. One hundred and seven samples from various clinical samples were collected from Obafemi Awolowo University Teaching Hospitals Complex, Ile-Ife, Nigeria. The isolates of S. aureuswere characterized and identified...
March 2009
Serum total cholesterol in hypertensive Northern Nigerians
Hypertension is associated with several lipid abnormalities including elevated total cholesterol (TC) concentrations. The presence of dyslipidaemia increases risks of cardiovascular morbidity and mortality. There is paucity of data on the pattern of serum TC in hypertensive patients in northern Nigeria. The objective of the present study was therefore to evaluate serum total cholesterol in hypertensive...
March 2009
Antibiotic susceptibility and plasmid pattern of Pseudomonas aeruginosa from the surgical unit of a university teaching hospital in north central Nigeria
This study determined the susceptibility pattern and multiple antibiotic resistance (MAR) index of 92 Pseudomonas aeruginosa strains from clinical samples comprising mainly urine (51.1%) and wounds (41.3%) obtained from the surgical units of Ahmadu Bello University Teaching Hospital, Zaria, Nigeria; over a 24-month period. The strains were susceptible to imipenem (94.6%), ciprofloxacin (90.2%), amikacin...
March 2009
Hepatocellular carcinoma: Risk factors, pattern of presentation and outcome in a tertiary health facility
Hepatocellular carcinoma is the fifth most common cancer in the world. Its incidence is increasing worldwide ranging between 3 and 9% annually. The aim of this study was to see the pattern of clinical presentation, identify the possible risk factors and the clinical outcome among HCC patients presenting at our health facility. The case records of all patients with histopathological diagnosis of HCC within the...
March 2009
Effect of metformin and folic acid on plasma homocysteine level in type 2 diabetic patients
Hyperhomocysteinemia is associated with an increased risk of cardiovascular disease in diabetic patients. The aim of this study was to evaluate effects of metformin and folic acid on plasma homocysteine level in diabetic patients. In this clinical trial 47 new cases of type 2 diabetes were randomized to two groups. We treated patients in trial group with metformin and 1 mg folic acid, whereas patients in control group...
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