December 2010
In silico sequence specific analysis of ERBB2 RTK alterations responsible for neuroectodermal tumors of Homo sapiens
Current theories of oncogenesis suggest that tumors develop as a result of sequential alterations, which activate or inactivate tumor suppressor genes involved in the regulation of the cell cycle, and ultimately over express or suppress the proteins derived from those genes. Mutation is an obvious way of constitutive activation of a kinase. Owing to the importance of ERBB proteins in both...
December 2010
Nine linked SNPs found in goat melanophilin (mlph) gene
Melanophilin (mlph) gene was characterized as the candidate gene for dilute coat color in human, mice and dog, but little is known in goat. Nine linked SNPs were found in goat mlph gene by sequencing a total of 108 individuals from 5 goat populations. No homozygous mutation of the linked SNPs was detected, so we made a hypothesis that the mutation allele might be or might be linked with a recessive...
