Journal of
Bioinformatics and Sequence Analysis

  • Abbreviation: J. Bioinform. Seq. Anal.
  • Language: English
  • ISSN: 2141-2464
  • DOI: 10.5897/JBSA
  • Start Year: 2009
  • Published Articles: 45

Table of Content: March 2011; 3(3)

March 2011

Molecular docking studies on oxidosqualene cyclase with 4-piperidinopyridine and 4-piperidinopyrimidine as its inhibitors

  Oxidosqualene cyclase (OSC) or Lanostrol Synthase is one of the major enzyme in cholesterol biosynthesis. OSC is involved in conversion of squalene to lanosterol. Increased level of cholesterol in blood leads to hypercholesterolemia and major risk factor for cardiovascular diseases. Statin drug molecule is developed to inhibit HMGCoA, which is the first enzyme of cholesterol biosynthesis showed major side...

Author(s): G. Jhansi Rani, M. Vinoth and P. Anitha  

March 2011

Polymorphisms in the transcription factor binding sites of host genes influences evolutionary susceptibility to falciparum malaria

  Gene expression at the level of transcription is regulated by a set of transcription factors (TFs) that recognizes cis elements. We accessed the human promoters from eukaryotic promoter database. These sequences have been run in P-match tool. MEME software has been used for detection of conserved sequences in the promoter region. All the predicted known TFs and their binding sites along with weight...

Author(s): Tabish Qidwai, Prabhash K. Pandey, Sangram Singh and Farrukh Jamal