April 2013

MLH1 gene: An in silico analysis

The MLH1 gene responsible for colon cancer has been examined to identify functional consequences of single-nucleotide polymorphisms (SNPs). 16 SNPs have been identified in the MLH1 gene in which all are found to be nonsynonymous. Non synymous SNPs are relevant in many of the human inherited diseases since they change the aminoacid sequence of the protein. 56% of the identified nsSNPs have been reported as damaging. In...

Author(s): Amitha Joy, Jubil, C. A, Syama, P. S and Rohini Menon

April 2013

Annotation of virulence factors in schistosomes for the development of a SchistoVir database

Scientific efforts in the eradication of neglected tropical diseases, such as those caused by the parasitic helminthes, can be improved if a database of key virulence factors directly implicated in pathogenesis is available. As a first step towards creating SchistoVir, a database of virulence protein factors in schistosomes, in this study, we curated, annotated and aligned sequences of twenty virulence factors...

Author(s): Adewale S. Adebayo and Chiaka I. Anumudu