January 2012

In silico structure assessment analysis of core domain of six protein data bank entries of HIV-1 Integrase

HIV integrase is a 32 kDa protein produced from the C-terminal portion of the Pol gene product, and is an attractive target for new anti-HIV drugs. Its main function is to insert the viral DNA into the host chromosomal DNA, a step that is essential for its replication. However there are six different Protein Data Bank (PDB) entries of the same protein with the same amino acids with PDB IDs 1BIS, 1BIU, 1BIZ, 1HYV, 1HYZ...

Author(s): Salam Pradeep Singh and B. K. Konwar

January 2012

In silico study of the binding parameters of various antioxidants with human Paraoxonase 1

Paraoxonases are a group of enzymes involved in the hydrolysis of organophosphates. Human Paraoxonase 1 is synthesized in liver and secreted into blood, where it is associated exclusively with High Density Lipoproteins and may protect against the development of atherosclerosis. Paraoxonase was identified as a genetic risk factor for cardiovascular disease. An enhancement of Paraoxonase 1 activity by well-known anti...

Author(s): K. Shyamala, Suhasini Cherine A., Nandha Devi E. and Deepa Gaauthem