July 2013

Does a protein coevolve with its multiple interacting partners? A case study

Protein-protein interactions are playing a fundamental role in different cellular activities.  Although the coevolution of interacting protein pairs has been established by several groups, whether a protein having multiple interacting partners coevolves with all of its interacting partners or not have not been studied, so far. Here, the coevolution of proliferating cell nuclear antigen (PCNA) with their multiple...

Author(s): Subinoy Biswas and Sudip Kundu