November 2014

Development of genodynamic metrics for exploring the biophysics of DNA polymorphisms

Single nucleotide polymorphisms (SNPs) represent an important type of dynamic sites within the human genome. These common variants often locally correlate within more complex multi-SNP haploblocks that are maintained throughout generations in a stable population. Information encoded in the structure of SNPs and SNP haploblock variation can be characterized through a normalized information content metric. Genodynamics is...

Author(s): James Lindesay, Tshela E Mason, William Hercules and Georgia M Dunston,