November 2013

Mapping Angiogenic Cells CD31 (PECAM1) and CD45 in PCa and BPH Biopsies

  Molecular characterization of PCa and BPH using the angiogenic tissue markers CD31 and CD45 to differentiate between the two major types of prostate gland disorders is investigated. 8 clinically characterized biopsies were analyzed at the Histopathology Laboratory of the Ekiti State University Teaching Hospital; the tissue sections were processed for antigen retrieval and were labeled with anti-CD45 and...

Author(s): Adegun P.T, Ogundele O.M, Falode D.T, Taiwo O.J, Ajonijebu D.C, Omoaghe A.O and Kobomoje O.S

November 2013

Solid-phase total synthesis of cyclic pentapeptide Longicalycinin A, by using 2-chlorotrityl chloride resin

Naturally isolated cyclic pentapeptide Longicalycinin A, which showed cytotoxicity to Hep G2 cancer cell line with an IC50 value 13.52 μg/mL, has been successfully synthesized by solid-phase methodology with Fmoc/t-Bu protecting schemes via solution-phase macrocyclization. 2-chlorotrityl chloride resin was used as solid support. Solution phase macrocyclization of linear pentapeptide precursor was carried out by two...

Author(s): Waqar Ahmad, Farzana Shaheen, Yunshan Zhou and Lijuan Zhang