September 2011

Chronic myeloid leukemia: Attributes of break point cluster region-abelson (BCR-ABL)

Chronic myeloid leukemia is a molecular fault from neoplastic transformation of hematopoietic stem cells. It is elicited by an extensive spectrum of “fused oncoproteins” which are necessitated in the disease refractoriness. It docks a miscellany of fusion transcripts originating from chromosomal rearrangements. Additionally, vulnerability to genomic rearrangements is particularly enhanced in chronic myeloid...

Author(s): Aamir Rana, , Sabir Hussain Shah, Nazia Rehman, Shaukat Ali, Ghulam Muhammad Ali, Shahzad Bhatti, and Ammad Ahmad Farooqi,

September 2011

Experimental therapy against ovarian cancer by tumor necrosis factor-related apoptosis-inducing ligand (TRAIL) gene driven by human telomerase reverse transcriptase (hTERT) promoter

TRAIL functions as a soluble cytokine killing various cancer cells with limited toxicity to most normal cells. Human telomerase reverse transcriptase (hTERT) promoter is known to selectively drive transgene expression in many human cancer cells. In this study, we aimed to determine whether the hTERT promoter could efficiently mediate more specific TRAIL gene therapy in ovarian cancer cells. We demonstrated...

Author(s): Hongmei Li and Yuecheng Yu