November 2011
Mesenchymal stem cells and acquisition of a bone phenotype: An ion channel overview
Bone remodeling is a physiological process determined by the sequential and coordinated interaction of osteocytes, osteoclasts, osteoblasts and angiogenesis. During bone repair, osteoblastic cells, originated from mesenchymal stem cells (MSCs), are highly regulated to proliferate and to produce an osteogenic matrix, thus forming a new bone. MSCs are multipotential and undifferentiated cells that are present in the adult...
November 2011
Achievement of balanced oncogenes and tumor-suppressor genes activity in normal and malignant cells in vitro and in vivo
The main goal is connected with providing, on the one hand, of active tumor-suppressor genes for prevention of eventual malignant transformations, and, on the other hand, of functionally active oncogenes for prevention of early aging and death, both in vitro and in vivo. Modulation of an adequate immune control was also necessary, and in this way any eventual unwished side effects from the genetic...
