February 2013

Association of insertion/deletion polymorphism of Alu angiotensin converting enzyme insertion/deletion genotype with type 2 diabetes mellitus and hypertension in J&K population: A case control study

The objective of the study is to know the frequencies of insertion/deletion (I/D) allele and association of angiotensin converting enzyme (ACE), I/D polymorphism in Jammu and Kashmir (J&K) populations in relation to type 2 diabetes mellitus (T2DM) and hypertension (HTN). A total of 500 individuals were recruited for the present study. Out of these 500 individuals, 250 individuals had T2DM and HTN and 250 were...

Author(s): Rakesh K. Panjaliya, Surbhi Sethi, Minakashee Sharma, Ravi Sharma, Parvinder Kumar and Subash Gupta

February 2013

Preparation and partial characterization of monoclonal antibody against human phosphdiesterase 5 (PDE5)

Phosphodiesterase 5 (PDE5) is a catalytic enzyme for degradation of cyclic guanosine monophosphate (cGMP) in human smooth muscle cells. Inhibition of this enzyme by certain chemicals including sildenafil, vardenafil and tadalafil, is considered a breakthrough treatment of erectile dysfunction. Unfortunately, these drugs are associated with several side effects. In this study, another strategy is adopted in the...

Author(s): Fawzi Alsheyab, Nizar Abuharfil, Mohanad Aldarouish, Dalal Awad and Yousef Mosameh