January 2011

Evaluation of glycemic control, gastric juice nitric oxide and oxidative stress in diabetic patients infected by Helicobacter pylori

Recently, diabetes mellitus has been known as one of the main cause of upper gastrointestinal symptoms. It has also been suggested that delayed gastric emptying may lead to bacterial overgrowth in the upper gastrointestinal tract. Since high prevalence of Helicobacter pylori (H. pylori) in diabetic patients has been reported. The aim of this study was to evaluate the relationship between dyspepsia, the level...

Author(s): Homayun Dolatkhah, Mohammad Rahbani-Nobar, Ebrahim Fattahi, Mohammad Ansari, Ahmad Mirza-Aghazadeh, Lida Eftekhari-Vash, Ashraf Fakhrjo and Amir Bahrami

January 2011

hTERT gene inhibition studies in cancer cells by using polysaccharide lentina

Lentinan a polysaccharide from medicinal mushroom that is Lentinus has been known to have anticancer properties. Telomerase activity is not observed in normal healthy cells, where as in cancerous cells telomerase expression is high. Telomerase represents a promising cancer therapeutic target. We investigated the inhibitory effect of lentinan on telomerase reverse transcriptase gene (hTERT) which is essential for...

Author(s): K. Sreenivasulu, M. Vijayalakshmi and K.R.S. Sambasiva Rao

January 2011

Evidence of association of a common variant of the endothelial nitric oxide synthase gene (Glu298 →Asp polymorphism) to coronary artery disease in South Indian population

Genetic variants of endothelial nitric oxide synthase (eNOS) could influence individual susceptibility to coronary artery disease (CAD) with or without association with demographic factors. This study was designed to assess the Glu298 /Asp variant of the eNOS gene in 79 patients with CAD as compared to equal number (79) of controls. The genotype frequencies for eNOS gene polymorphism were determined by PCR and RFLP, and...

Author(s): Rabbani Syed, Moin Uddin Biyabani, Shiva Prasad, Farha Deeba, and Kaiser Jamil