Journal of
Medical Genetics and Genomics

  • Abbreviation: J. Med. Genet. Genomics
  • Language: English
  • ISSN: 2141-2278
  • DOI: 10.5897/JMGG
  • Start Year: 2009
  • Published Articles: 48

Table of Content: January 2014; 6(1)

January 2014

The codon 17 polymorphism of the CTLA4 gene in type 1 diabetes mellitus in the Baghdad population

The aim of this work was to study the polymorphism in CTLA4 gene in insulin-dependent diabetes mellitus (IDDM) type I patients in Baghdad population. To achieve this goal, blood samples were collected from 80 IDDM (40 males and 40 females) and 20 samples of healthy, DNA was isolated and the CTLA4 gene (A 152 bp fragment) were amplified by using specific primers for exon1 of this gene, and then found the sequence of this...

Author(s): Najwa S. H. Ahmed

January 2014

Mutation N308T of protein tyrosine phosphatase SHP-2 in two Senegalese patients with Noonan syndrome

Noonan syndrome is a genetic autosomal dominant disorder characterized by facial dysmorphy, short stature, delayed puberty and congenital heart defects. The first gene implicated in this syndrome is PTPN11, encoding protein tyrosine phosphatase SHP-2. Several studies worldwide have identified missense mutations in this gene in patients with Noonan syndrome. Our objective focused on mutations screening of PTPN11 on a...

Author(s): Rokhaya Ndiaye, Coumba Ndiaye, Mohamed Leye, Babacar Mbengue, Mama Sy Diallo, Jean Pascal Demba Diop, Omar Faye, Ibrahima Bara Diop and Haby Signaté Sy

January 2014

A study of correlation between CYP2C9 gene polymorphism and Warfarin maintenance dose in anticoagulant therapy among Han people in Yunnan of China

In this study, we investigated the correlation between CYP2C9 gene polymorphism and maintenance dose of Warfarin in 300 patients who were the Han population derived from the Affiliated Yan An Hospital of Kunming Medical University in Yunnan Province of China, subjected to the operation of cardiac valve replacement and Warfarin oral administration post operation from 2008 to 2009 by detecting the genotypes and Allele...

Author(s): ZhiYu Chen, Jintao Li, Xuemei Dong, JianXing Liu, Hui Gao, Liping Zhao and BingYing Xu