May 2011

Antisense therapy, a magic bullet for the treatment of various diseases: Present and future prospects

Antisense oligonucleotides (ASO) are becoming more widely accepted as potential therapeutics for various diseases. Antisense therapy has emerged as an exciting and promising strategy for the treatment of various diseases. Antisense are different from conventional drugs that are designed to interact with protein molecule. Antisense drugs have more selective action and they have the potential to be more effective and less...

Author(s): Jyotsna A. Saonere

May 2011

The effects of mitochondrial dysfunction in schizophrenia

Mitochondria are unique and important organelles in terms of energy production for the eukaryotic cell. Through complexes of the electron transport chain embedded in the mitochondrial membrane, the cell is able produce large amounts of ATP. Mitochondria posses their own genome, some of which encodes for the subunits of these protein complexes. From the comorbidity of psychotic symptoms seen in those with mitochondrial...

Author(s): Maryann Manatt and Sathees B. Chandra

May 2011

An improving DNA isolation method for identification of anaerobic bacteria in human colostrum and faeces samples

The efficiency, with which the lysis of 20 anaerobic bacterial samples [8 different bacterial species isolated from 4 colostrum and 4 infants (which are fed only by breast milk and from 3 to 30-day-old) faeces] were lysed, was tested using a reference or an improving method that involves higher levels of lysozyme (Sigma-Aldrich) and proteinase K solution (Sigma-Aldrich). Eight species were lysed with the efficiency of...

Author(s): Hasibe Cingilli Vural and Dilek Ozgun