October 2015

Plasma von Willebrand factor level and its associated parameters: Reference ranges in Nigeria

Von Willebrand factor (VWF) is a complex multimeric, multifunctional glycoprotein. It plays a primary role in haemostasis by forming platelet plugs at sites of vascular injury. The biological breakdown of VWF is mediated by a metalloprotease, ADAMTS-13. Both proteins are important in normal coagulation. Deficiencies in gene and or protein of VWF are associated with von Willebrand disease and those of ADAMTS-13 are...

Author(s): Eyiuche D Ezigbo, Ernest O Ukaejiofo and Ijeoma Chinyeaka