March 2012
Changes in oestrous cycle of adult female wistar rats treated with artemether
Artemether is an ante malaria that has proved rapidly effective. It has replaced chloroquine and quinine is many parts of the world. This is an experimental study designed to examine the effects or artemether on oestrous cycle of lower primates since this drug is highly consumed by females in child bearing age. Twenty four cyclic female rats were randomly divided into three groups A, B and C all administered 10 mg/kg...
March 2012
Some changes in the cerebellar weights and Purkinje cells in adult Wistar rats following experimental artesunate administration
This study assessed the effects of artesunate on the Purkinje cell density and transverse diameters in the cerebellar cortex of Wistar rats. Twenty four Wistar rats were separated into four groups. Groups A, B and C orally received 4 mg/kg body weight of artesunate on day 1. Group A continued with this dosage for the next 3 days while rats in groups B and C received 2 mg/kg once daily for the next 6 and 13 days...
March 2012
Intrauterine infection promotes brain region specific cytokine activation and hyperactivity in developing rat
Intrauterine infection during pregnancy is associated with premature birth, periventricular leukomalacia, early activation of the fetal immune system and poor neurodevelopmental outcomes. Previous clinical studies and studies with animal models have shown increased activation of the immune system evidenced by increased levels of inflammatory cytokines, white matter damage and delays in behavioral development. Animal...
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