March 2011
Disposition of quinine and its major metabolite, 3-hydroxyquinine in patients with liver diseases
Quinine, extensively metabolized by CYP 3A4, has 3-hydroxyquinine as the major metabolite which also contributes to its antimalarial activity. This study assessed the impact of various liver diseases on the disposition of quinine and 3-hydroxyquinine. Ten adult patients with liver diseases ranging from cirrhosis, primary liver carcinoma, hepatitis, ascites, and amoebic liver disease as well as six healthy...
March 2011
Clinical epidemiological investigation of moldy grain and fodder poisoning in goat in Kathmandu Valley - A technical report
An outbreak of a syndrome of unknown etiology associated with the feeding of moldy maize grain and green fodder to goat in a herd of male 3853 goats for sale for the Dashahara festival during the month of October, 2010 in Kathmandu Valley. In a period of 10 days 500 goats suddenly became ill with symptoms of anorexia, apathy, diarrhea and ruminal stasis. On clinical examination these goats were provisionally...
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