Research in Pharmaceutical Biotechnology

  • Abbreviation: Res. Pharm. Biotech.
  • Language: English
  • ISSN: 2141-2324
  • DOI: 10.5897/RPB
  • Start Year: 2009
  • Published Articles: 43

Table of Content: March 2011; 3(3)

March 2011

Disposition of quinine and its major metabolite, 3-hydroxyquinine in patients with liver diseases

  Quinine, extensively metabolized by CYP 3A4, has 3-hydroxyquinine as the major metabolite which also contributes to its antimalarial activity. This study assessed the impact of various liver diseases on the disposition of quinine and 3-hydroxyquinine. Ten adult patients with liver diseases ranging from cirrhosis, primary liver carcinoma, hepatitis, ascites, and amoebic liver disease as well as six healthy...

Author(s): Chinedum P. Babalola, Olayinka A. Kotila, Patrick A. F. Dixon and Adefemi E. Oyewo

March 2011

Clinical epidemiological investigation of moldy grain and fodder poisoning in goat in Kathmandu Valley - A technical report

  An outbreak of a syndrome of unknown etiology associated with the feeding of moldy maize grain and green fodder to goat in a herd of male 3853 goats for sale for the Dashahara festival during the month of October, 2010 in Kathmandu Valley. In a period of 10 days 500 goats suddenly became ill with symptoms of anorexia, apathy, diarrhea and ruminal stasis. On clinical examination these goats were provisionally...

Author(s):   Kedar Karki