November 2009
Neuropharmacological effects of Sorghum bicolor leaf base extract
The neuropharmacological effects of aqueous methanolic extract of leaf base ofSorghum bicolor were studied on Wistar rats and Swiss albino mice; evaluations were done on spontaneous motor activity, exploratory behaviour, apomorphine-induced stereotypic behaviour, pentobarbitone sleeping time and rota-rod performance for motor coordination. The results showed a significant (P < 0.05) reduction in the...
November 2009
Synthesis, antimicrobial potential and toxicological activities of Ni(II) complex of mefloquine hydrochloride
Transition metal complex of Ni(II) with mefloquine hydrochloride (antimalaria drug) was synthesized using a template method. Chemical analysis including conductivity measurements and spectroscopic studies were used to propose the geometry and mode of binding of the ligand to metal ion. From analytical data, the stoichiometry of the complex has been found to be 1:1. Infrared spectral data also suggest that the...
