October 2012
Drug-drug interactions in ageing HIV-infected individuals
The effectiveness of antiretroviral therapy has significantly improved life expectancy of HIV-infected individuals. Global campaigns and awareness programmes have led to substantial drop in the rate of new infections. Consequently, the proportion of ageing HIV-infected individuals continues to increase. HIV-associated and age-related comorbidity necessitates polypharmacy in ageing individuals living with HIV/AIDS. The...
October 2012
Effects of PEGylation on the Lowry method for the content determination of trichosanthin
The current study was designed to establish a method for examining whether the content of PEG-TCS could be determined by the Lowry method. The research applicability of the Lowry method on the determination of PEGylated trichosanthin (PEG-TCS) protein content was proposed for the first time. Procedures were designed to determine whether residual PEG interfered with the result of protein content determination, PEG...
October 2012
Induction of remifentanil by bradycardia and hypotension through distinct biochemical mechanisms
Remifentanil has been well known to cause much more significant bradycardia and hypotension as compared with other opioids. However, the underlying mechanism is still poorly understood. The present study hypothesized that remifentanil led to bradycardia and hypotension with distinct mechanisms and aimed to test this hypothesis. Testing the hypothesis would broaden our understanding the underlying mechanism of...
October 2012
Effects of supplementing qi and activating blood circulation herbs on expressions of basic fibroblast growth factor and platelet endothelial cell adhesion molecule-1 in ischemic myocardium of rats with acute myocardial infarction
The objective of this study was to investigate the effects of supplementing qi and activating blood circulation herbs on the expressions of basic fibroblast growth factor (bFGF) and platelet endothelial cell adhesion molecule (PECAM-1) in ischemic myocardium of rats with acute myocardial infarction (AMI). Acute myocardial infarction (AMI control) of male Sprague-Dawley rats was established by ligating left anterior...
October 2012
Expression and significance of glyceraldehyde-3-phosphate dehydrogenase in patients with osteosarcoma
To observe the expression of glyceraldehyde-3-phosphate dehydrogenase (GAPDH) in patients with osteosarcoma and its relationship with surgical stage, 60 patients with osteosarcoma, including 20 cases in Stage I, 17 cases in Stage II and 23 cases in Stage III were sequentially enrolled in this study. The expression of GAPDH in osteosarcoma and osteochondroma tissues on mRNA and protein levels were measured by fluorescent...
October 2012
Up-regulation of heme oxygenase-1 by sevoflurane attenuates LPS-induced acute lung injury in a rat model
To investigate heme oxygenase-1(HO-1) expression induced by sevoflurane in lipopolysaccharide (LPS)-induced acute lung injury (ALI). Forty-eight rats were randomly designated into six groups to receive normal saline (NS), ZnPPIX(a specific HO-1 inhibitor), or sevoflurane: A (control, NS only), B (ZnPPIX only), C (sevoflurane only), D (LPS + 1.0 minimum alveolar concentration (MAC) sevoflurane), E (ZnPPIX...
October 2012
Acupuncture effect on the magnetic resonance imaging (MRI) test for mild cognitive impairment leukoaraiosis
Vascular cognitive impairment refers to the risk factors derived from blood vessels caused by a variety of levels and types of cognitive impairment, such as vascular mild cognitive impairment, vascular dementia and mixed dementia. Using acupuncture for mild cognitive impairment leukoaraiosis has impacts on the functional magnetic resonance. To know the neurotransmitter changes before and after acupuncture intervention...
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