September 2014
Formulation development of immediate release chlorpropamide tablets using directly compressible excipients
Diabetes mellitus is a major cause of morbidity and mortality worldwide. Chlorpropamide is an oral antidiabetic drug belonging to sulphonyl urea group, frequently prescribed in the treatment of type II diabetes mellitus. The present study was aimed on adopting cost effective direct compression method for the development of immediate release tablets of chlorpropamide by employing Avicel PH 102 and pregelatinized starch...
September 2014
In vitro effects of Eugenia pyriformis Cambess., Myrtaceae: Antimicrobial activity and synergistic interactions with Vancomycin and Fluconazole
The Eugenia pyriformis Cambess. species, Myrtaceae, also known by the popular name as uvaia was evaluated for its antimicrobial activity. Broth microdilution method was used to determine the Minimum Inhibitory Concentration (MIC) against selected pathogenic strains of bacteria, and fungi. Checkerboard method was used to evaluate the synergistic interactions of E. pyriformis with Vancomycin and Fluconazole. The leaf and...
September 2014
Technological development and evaluation on sialagogue activity of a spray-like liquid formulation of pilocarpine
Xerostomia is a common condition in patients undergoing oncological treatment. As a result of adverse effects of drugs or as an answer to radiotherapy radiation, the salivary glands of mouth stop or reduce the production and secretion of saliva. This leads to severe consequences such as caries, infections, difficulty in swallowing, and sensory loss. Thus, this work aimed to develop a new product to be used in patients...
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