January 2014

Isolation and characterization of an anti-microbial biflavonoid from the chloroform-soluble fraction of methanolic root extract of Ochna schweinfurthiana (Ochnaceae)

The chromatographic investigation of the chloroform soluble fraction of methanolic root extract of Ochna schweinfurthiana using a combination of silica and sephadex LH-20 led to the isolation of tri-methoxy derivative of lophirone A. The structure of this new compound was determined using both 1 and 2D nuclear magnetic resonance (NMR). The antimicrobial activity of the isolated compound was also investigated using agar...

Author(s): Abdullahi M. I., Musa A. M., Haruna A. K., Pateh U. U., Sule I. M., Abdulmalik I. A., Abdullahi M. S., Abimiku A. G. and Iliya I.

January 2014

Latent natural product and their potential application as anti-infective agents

Extract of Acorus calamus (AC) and Ferula asafetida (FA) were tested against different bacterial pathogens by well-cut agar diffusion method. To analyzed the in vitro activities of A. calamus and F. asafetida, four different bacteria (Escherichia coli, Staphylococcus epidermidis, Staphylococcus aureus and Bacillus subtilis) were used. A. calamus had a broad spectrum antimicrobial effect against different bacterial...

Author(s): Fatima Syed, Raheela Taj, Nusrat Shaheen, Musarat Norin and Shafiullah Khan,

January 2014

The effect of medium chain saturated fatty acid (monolaurin) on levels of the cytokines on experimental animal in Entamoeba histolytica and Giardia lamblia infection

The aim of this study was to demonstrate the effect of medium chain saturated fatty acid (monolaurin) on experimentally infected Giardia lamblia and Entamoeba histolytica, and measurement of IFN-γ, TNF-α, IL-4, IL-10, TGF-β levels of cytokines. To study the effect of monolaurin on the duodenal mucosa of the studied infected hamsters, a group of sixty golden Syrian hamsters were used, which were further...

Author(s): Zeinab Hassanein Fahmy, Eman Aly, Ibrahim shalsh and Amira H. Mohamed

January 2014

Puerarin inhibits acute nociceptive responses via the P2X3 receptor in rat dorsal root ganglia

The effects of puerarin on acute nociception mediated by the P2X3 receptor in rat dorsal root ganglia (DRG) were studied. Intrathecal injection of adenosine triphosphate (ATP) or α,β-methylene-ATP (α,β-meATP) could potentiate acute nociceptive responses induced by intraplantar injection of ATP or α,β-meATP in rat hindpaw. Intraplantar injection of formalin increased the expression of...

Author(s): Changshui Xu, Bo Fan, Shicheng Yu, Shuangmei Liu, Huangui Xiong, Yun Gao, Guilin Li, Hong Xu, Xiaoli Tang, Qicheng Zhu, Chaoran Zheng, Bing Wu, Lichao Peng, Miaomiao Song, Qin Wu and Shangdong Liang