April 2014
Surfactants solubility, concentration and the other formulations effects on the drug release rate from a controlled-release matrix
Surfactant effects on the drug release from controlled release systems have been widely studied. These effects are dependent on the surfactant physical properties such as structure, charge, solubility and concentration. In addition, presence of excipients in the matrices can modify the surfactants effects. Here we investigated the effects of surfactant solubility and concentration of excipients on the drug release. Two...
April 2014
Quantification of propranolol in rat plasma by LC-MS/MS using tramadol as an internal standard: Application to pharmacokinetic studies in TAA-induced liver fibrotic rats
A simple, rapid and selective liquid chromatography coupled with tandem mass spectrometry (LC-MS/MS) is developed and validated for quantification of propranolol without the sample extraction step in rat plasma using tramadol as an internal standard (IS). The analytes are separated using an isocratic mobile phase which consist of methanol and 10 mm ammonium formate (70/30, v/v) on an isocratic UK-C18 (Imtakt Unison 2.0...
Advertisement
Advertisement
