July 2010

Possible role of 2, 2’- (Diazinodimethylidyne) di - (o-phenylene) dibenzoate, a novel hydrazine as an anti – HIV agent

A number of anti-HIV agents act by inhibiting specific steps in the lifecycle of HIV.  Inhibition of reverse-transcriptase (RT), a multi-functional enzyme is an important option. The interaction of 2, 2´-(Diazinodimethylidyne)-di-(o-phenylene)-dibenzoate (HZ) with HIV1-RT was studied to explore its possible use in anti-HIV therapy. This novel hydrazine derivative undergoes strong interaction with a number of...

Author(s): Rita Ghosh, Dipanjan Guha, Sudipta Bhowmik and Angshuman Bagchi

July 2010

Comparative study of inhibition of drug potencies of c-Abl human kinase inhibitors: A computational and molecular docking study

Structural studies suggest that the c-Abl protein kinase domain exists in two conformations; an active and an inactive form. There are many inhibitors which bind this tyrosine kinase in both forms. Many of these kinase inhibitors are in clinical trials too. The inhibition potency of these inhibitors is a common topic of discussion. In the present study we have taken a library of eight different inhibitors and docked...

Author(s): D. Kshatresh Dubey, K. Amit Chaubey, Azra Parveen and P. Rajendra Ojha