April 2012

Analysis of structurally conserved atomic interactions in structural homologs of nicotinamide adenine dinucleotide binding dehydrogenases

The stability of protein-ligand complex is decided by the strength of the forces and interaction that holds the overall structure. The binding of ligand to its receptor involves the participation of atomic interactions of key conserved amino acid residues which are essential for functional and structural integrity of protein molecule. Understanding the binding mechanism of ligand to its receptors is important in...

Author(s): P. S. Solanki, M. Krishna Mohan, P. Ghosh and S. L. Kothari

April 2012

A computational analysis to understand the role of DmsD in the biosynthesis of dimethyl sulfoxide (DMSO) reductase

The role of DmsD in the biosynthesis of dimethyl sulfoxide (DMSO) reductase is quite controversial. Several studies have indicated its role as ‘proof-reading chaperone’, which might function to prevent the translocation of misfolded and non-cofactor containing protein. DmsD is also shown to bind to the signal peptide; however, its possible function as a ‘guidance factor’ for membrane targeting is...

Author(s): Nazlee Sharmin