February 2012

A new biophysical metric for interrogating the information content in human genome sequence variation: Proof of concept

The 21st century emergence of genomic medicine is shifting the paradigm in biomedical science from the population phenotype to the individual genotype. In characterizing the biology of disease and health disparities in population genetics, human populations are often defined by the most common alleles in the group. This definition poses difficulties when categorizing individuals in the population who do not have...

Author(s): James Lindesay, Tshela E. Mason, Luisel Ricks-Santi, William Hercules, Philip Kurianand Georgia M Dunston,

February 2012

Potential of mangrove derived compounds against dihydrofolate reductase: An in-silico docking study

Approximately 3 billion people, one half of the world’s population, live in at-risk regions for malaria infection leading to about 250 million malaria cases every year and nearly one million deaths. Once the malarial parasite Plasmodium vivax and Plasmodium falciparum enters the red blood cells its growth is inhibited by Proguanil, a prophylactic antimalarial drug which inhibits the...

Author(s): Senthilraja P., Sunil Kumar Sahu and Kathiresan K.