November 2011

Methylene-tetrahydrofolate reductase (MTHFR) gene polymorphisms and bladder cancer susceptibility: A meta-analysis that includes race, smoking status and tumor stage

Epidemiological studies have investigated that functional polymorphisms in methylene-tetrahydrofolate reductase (MTHFR) gene may play an essential role in bladder carcinogenesis, but the several published studies have reported inconclusive results. The objective of the current study is to conduct an update analysis investigating the association between polymorphisms in MTHFR gene and the risk of bladder cancer. We...

Author(s): Kamel Rouissi, Sami Khedhiri , Soumaya Kouidhi, Slah Ouerhani, Mohamed Cherif, and Amel Benammar-Elgaaied

November 2011

Elucidate the origin of CYP flexible structural variation using molecular dynamics calculation

Human cytochrome P450 1A2 (CYP1A2) plays a critical role in the mechanism of drug metabolism the understanding of which constitutes a cornerstone in drug design processes. Its relevance has furthered in view of recent trends in tailor made medicine, since the enzyme's activity differs according to the mutations orsingle nucleotide polymorphisms (SNP's) in the respective genetic coding region. Here...

Author(s): Mohamed Ismael and Carlos A. Del Carpio