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GSTM1 and T1 null variants effects on predisposition to Type 2 Diabetes Mellitus in Turabah population, Saudi Arabia

Type 2 Diabetes Mellitus (T2DM) is characterized by chronic hyperglycemia and associated with an increased production of reactive oxygen species (ROS) affecting beta cells in pancreas. Glutathione S-transferases (GSTs) are a family of antioxidant enzymes that include several classes of GSTs. These enzymes have important roles in decreasing ROS species and act as a kind of antioxidant defense. In a case-control study we...

Author(s):Adil Mergani, Ahmed A. Mansour, Osama M. Saleh , Rasha N. Zahran, Adil M. Mustafa, Mukhtar A. Mohammed and Tamer Askar

Article in Press

Lycopene attenuates diabetes-induced oxidative stress in Wistar rats

The purpose of this study is to evaluate the capacity of lycopene against diabetes-induced oxidative damage in Wistar rats. Thirty Wistar rats of both sexes, twenty-five of which were diabetic, were used. Diabetes was induced by single intraperitoneal injection of streptozotocin (STZ) 60 mg/kg body weight and it was confirmed by the elevated blood glucose ≥200 mg/dl after three days. The rats were divided randomly into...

Author(s):Ejike Daniel Eze, Adam Moyosore Afodun, Sheu Oluwadare Sulaiman, Nganda Ponsiano, Iliya Ezekiel, Moses Dele Adams, Alfred Omachonu Okpanachi and Karimah Mohammed Rabiu