Despite advancements in detecting and treating diabetes, its incidence continues to increase; thus, early screening measures such as DNA tests in patients at high risk of developing diabetes melli-tus may result in early management. Patients with diabetes mellitus (DM) risk factors proposed by the American Diabetes Association were conducted a nutrigenetic test screening in 4 genes in-volved in glucose and lipid metabolism. 26 patients were in the high-risk (HR) group and 38 were in the low-risk (LR) group; basal insulin, glycemia and the HOMA-IR score were evaluated. Mean age of participants in HR group was 47 (± 8.37) and 43 years (± 10.57) in the LR group, 69% of participants were male and 53% were female, respectively. In both groups the mean of body mass index (BMI) was 27.3 (± 3.86) kg/m2. The PPARG, SLC2A2, TCF7L2, FTO genes showed some variation between HR and LR groups, but none reached statistical significance. High risk indi-viduals had an increased DM risk up to 3.7 times based on genetic variants of TCF7L2. Partici-pants with genetic changes had up to 2.7 times higher than average risk for developing insulin re-sistance, but no statistical significance was obtained.

Keywords: Insulin resistance; Diabetes mellitus 2; Biotechnology; DNA tests; Diabetes Prevention.