December 2016

Acute and sub-chronic toxicity study of the extract and powder of Operculina macrocarpa (L.) Urb. in mice

The aim of the study was to evaluate the experimental acute and sub-chronic toxicities of Operculina macrocarpa with plant extract and powder, respectively, in male and female mice. Phytochemical prospection was performed with extract and administration in single doses by intraperitoneal route to six groups and control at 1230, 970, 700, 350, 120 and 30 mg/kg doses and distilled water (0.1 ml/10 g), respectively....

Author(s): Carpejane Ferreira da Silva, Ana Célia Rodrigues Athayde, Marcílio Fontes Cezar, Onaldo Guedes Rodrigues, Sergio Santos Azevedo, José Galberto Martins da Costa and Fabrício Kleber de Lucena Carvalho

December 2016

Ex vivo trypanostatic effect of stem-bark extracts of Securidaca longipedunculata (Fres. Holl) against Trypanosoma brucei brucei

Current treatment of trypanosomosis in sub-Saharan Africa is associated with widespread inefficiency. There is therefore the need to find more effective drugs against the disease from promising traditional medicinal herbs. This work is aimed at evaluating ex vivo anti-trypanosomal effect of stem-bark extracts of S. longipedunculata against T. brucei brucei. One hundred microlitre of crude methanol, ethyl acetate and...

Author(s): Abdullah Mohammad Tauheed, Mohammed Musa Suleiman, Mohammed Mamman, and Idris Alao Lawal