African Journal of
Cellular Pathology

OFFICIAL PUBLICATION OF THE SOCIETY FOR CELLULAR PATHOLOGY SCIENTISTS OF NIGERIA
  • Abbreviation: Afr. J. Cell. Path
  • Language: English
  • ISSN: 2449-0776
  • DOI: 10.5897/AJCPath
  • Start Year: 2013
  • Published Articles: 68

Impact of liver damage on the histoarchitectural profile of the cerebellar cortex in rats

Adekomi DA
  • Adekomi DA
  • Department of Anatomy, College of Medicine and Health Sciences, Afe Babalola University, Ado Ekiti, Ekiti State, Nigeria.
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Oyesomi TO
  • Oyesomi TO
  • Department of Anatomy, College of Medicine, Ekiti State University, Ado Ekiti, Ekiti State, Nigeria.
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Ajao MS
  • Ajao MS
  • Department of Anatomy, Faculty of Basic and Medical Sciences, University of Ilorin, Ilorin, Kwara State, Nigeria.
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Ojo OA
  • Ojo OA
  • Department of Chemical Sciences (Biochemistry Unit), Afe Babalola University, Ado Ekiti, Ekiti State, Nigeria.
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Onikanni SA
  • Onikanni SA
  • Department of Chemical Sciences (Biochemistry Unit), Afe Babalola University, Ado Ekiti, Ekiti State, Nigeria.
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  •  Received: 01 October 2013
  •  Accepted: 01 November 2013
  •  Published: 30 November 2013

Abstract

Aim: This study described the histopathological profile of the cerebellar cortex and liver of rats with carbon tetrachloride (CCl4)-induced liver damage.

Methods: Male Wistar rats weighing about 250 g were divided into 2 groups (A and B). Group A (control) rats were treated with olive oil (OO) solution only while Group B rats were treated with carbon tetrachloride (CCl4) for 8 weeks. Thereafter, the cerebellum and liver of the rats were processed and stained with cresyl fast violet and H&E, respectively, for histopathological examinations of the cerebellar cortex and liver.

Result: Histopathological analysis shows cortical necrosis, uneven neuronal loss with varying range of vacuolations in the cerebellar cortices and moderate vascular congestion and extensive cytoplasmic damage on the hepatocytes of the CCl4 treated rats.

Conclusion: There is of loss of hepatic function in the CCl4 treated rats.

 

Key words: -Neurons, Neuropathology, Vacuolations, Necrosis, Neuronal loss.