African Journal of
Cellular Pathology

OFFICIAL PUBLICATION OF THE SOCIETY FOR CELLULAR PATHOLOGY SCIENTISTS OF NIGERIA
  • Abbreviation: Afr. J. Cell. Path
  • Language: English
  • ISSN: 2449-0776
  • DOI: 10.5897/AJCPath
  • Start Year: 2013
  • Published Articles: 66

Effect of a cassava based diet (gari) on some renal function parameters in albino rats

Adegoke O.A
  • Adegoke O.A
  • Department of Medical Laboratory Science, Madonna University,Elele, Nigeria
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Bamigbowu E.O
  • Bamigbowu E.O
  • Department of Chemical Pathology, University of Port Harcourt, Port Harcourt, Nigeria
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George–Opuda M. I
  • George–Opuda M. I
  • Department of Medical Laboratory Science, Rivers State University of Science and Technology, Port Harcourt, Nigeria
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Awopeju T A
  • Awopeju T A
  • Department of Medical Microbiology and Parasitology, University of Port Harcourt, Port Harcourt, Nigeria
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Mbata C A
  • Mbata C A
  • Department of Medical Laboratory Science, Rivers State University of Science and Technology, Port Harcourt, Nigeria
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Braide S A
  • Braide S A
  • Institute of Pollution Studies, Rivers State University of Science and Technology, Port Harcourt, Nigeria
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Ekwusa O. V
  • Ekwusa O. V
  • School of Medical Laboratory Science, University of Port Harcourt Teaching Hospital, Port Harcourt, Nigeria
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Odunfa T
  • Odunfa T
  • Department of Medical Laboratory Science, Rivers State University of Science and Technology, Port Harcourt, Nigeria
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  •  Received: 01 May 2015
  •  Accepted: 01 June 2015
  •  Published: 30 June 2015

Abstract

Aim: The study was carried out to ascertain the effect of Gari (a cassava based diet) on renal functions in albino rats.

Methods: Thirty five Wistar albino rats divided into seven groups were fed Gari mixed with normal rat diet at concentrations of 0, 10, 20, 40, 60, 80, and 100% respectively for 3 weeks and the renal parameters (Creatinine, Urea, Sodium and Potassium) monitored in the animals.

Results: There were dose dependent increases in urea, creatinine, potassium and sodium of albino rats fed Gari diet. Using analysis of variance (ANOVA), there were significant differences in the urea, and creatinine concentrations when compared to their respective controls (P<0.05) while sodium and potassium did not show any significant difference (P>0.05).

Conclusion: Therefore this study showed that Gari caused changes in renal function based on the concentration of the Gari.

Keywords : Renal, Gari, Creatinine, Urea, Electrolytes