Aim: This study was aimed at investigating the effects of Datura metel (D. metel) on the histology of the lungs and liver in rat models.

Methods: Twenty rats were divided into four groups of five each. D. metel extract was administered (50, 100 and 150mg/kg) to the rats through an orogastric tube once daily for 21days.

Results: The histomorphological parameters showed thin atrophic and collapsed alveolar sacs (Atelectasis) in the lungs. In the liver there was severe ballooning degeneration of hepatocytes. Biochemical parameters revealed significant decreases (p<0.01 and p<0.05) in chloride experimental groups (70.60±1.5 and 74.00±6.9) and HCO-3 also increased significantly (p<0.01) in the second group (17.80±8.07). The level of urea concentration in serum increased but was not significant in all the experimental groups (7.38±0.3, 7.27±1.9 and 7.30±1.3) as well as Creatinine (11.00±1.22, 40.25±1.2, 58.00±30.5) when compared with their

controls (6.13±0.2 and 47.50±3.4).

Conclusion: The result of administration of Datura metel in rat model is suggestive of pulmonohepatic and kidney toxicity at a concentration of 50mg/kg. 

 

Key words: Pulmonary, Ballooning degeneration, Histopathology, Liver, Lungs