Aim: In order to determine possible linkages between the onset of prostate cancer and some lipid characteristics, the levels of Prostate Specific Antigen (PSA) and Lipid characteristics of prostate and non -prostate cancer subjects were evaluated.

Methods: Blood samples were collected from 100 subjects; 50 of whom had newly been diagnosed for prostate cancer but had not yet been on medication and the other 50 as non -prostate cancer subjects. Fasting Blood samples were collected for Lipid Profile and PSA.

Results: The age range of the subjects was from 40-89 years. 84% of diseased subjects were within the age range of 50-79 years while 34% fell within the 70-79 years age range. Mean levels of PSA, Total Cholesterol, Triglycerides, HDL and LDL in the Prostate cancer subjects were respectively as follows: 51.50 ± 39.05μg/l; 6.37 ± 1.63mmol/l; 1.90± 0.59mmol/l; 0.91 ± 0.18 mmol/l and 4.44 ± 1.46 mmol/l. On the other hand, the Mean PSA, Total Cholesterol, Triglycerides, HDL and LDL in the Control subjects were 2.12± 1.40μg/l; 4.08± 1.03mmol/l; 1.23±0.48mmol/l and 2.53±0.88mmol/l respectively. The correlation matrix showed a moderately positive correlation between PSA and Cholesterol(r=0.43) and between PSA and LDL(r=0.38).

Conclusion: Advanced age, high PSA, Total cholesterol, Triglycerides and LDL levels may be predisposing factors to the incidence of prostate cancer, while high HDL may inhibit the onset of the disease.

 

Key words: Prostate Specific Antigen, Lipid profile, Cancer