Abstract

Aim: The aim of this study was to investigate the effect of honey and Aloe vera extract on Aspirin-induced liver damage in albino rats.

Methods: A total of twenty four adult male albino rats weighing between 100 and 150g were divided into six groups. (A, B, C, D, E and F) of four rats each in a group, Rats in Group A served as control and were given water and feeds only. Rats in Group B were given 100mg/kg of aspirin only, 100mg/kg of

aspirin was administered to rats in Group C and 1.0ml of Aloe vera was administered to rats in Group D, rats in Group E were administered Aloe vera extract only while rats in Group F were administered with 100mg/kg of aspirin, 1.0ml of Aloe vera and 1.0ml of honey. The administration was done orally.

Results: The results showed significant decrease (P<0.05) in the PCV and haemoglobin level of test groups compared with the control. Groups treated with aspirin had the highest WBC count of 5.83× 103 (±0.03) while the control group had the lowest WBC count of 2.7× 103 (±0.03). Histopathological

findings indicate severe dilation of blood vessel, necrosis of vascular connective tissues, wide spread vacuolar degeneration, edema and bile duct hyperplasia. The study revealed that honey and Aloe vera extract had hepato protective and hepato curative effects.

Keywords: Honey, Aloe vera, Aspirin, Hepatotoxic, Liver.