African Journal of
Cellular Pathology

OFFICIAL PUBLICATION OF THE SOCIETY FOR CELLULAR PATHOLOGY SCIENTISTS OF NIGERIA
  • Abbreviation: Afr. J. Cell. Path
  • Language: English
  • ISSN: 2449-0776
  • DOI: 10.5897/AJCPath
  • Start Year: 2013
  • Published Articles: 60

Effect of exercise induced stress on serum cortisol level and cd4 cell count in rats

Ehiaghe FA
  • Ehiaghe FA
  • Department of Hematology, College of Health Sciences, Igbinedion University, Okada. Nigeria.
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Agbonlahor DE
  • Agbonlahor DE
  • Lahor Research and Medical Centre, 121, Old Benin –Agbor Road, Benin City, Nigeria.
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Etikerentse SMO
  • Etikerentse SMO
  • Department of Hematology, College of Health Sciences, Igbinedion University, Okada. Nigeria.
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Osadolor HB
  • Osadolor HB
  • Department of Medical Laboratory Science, University of Benin, Benin City, Nigeria.
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  •  Received: 01 October 2013
  •  Accepted: 01 November 2013
  •  Published: 30 November 2013

Abstract

Aim: To evaluate the effect of exercise induced stress on serum cortisol level and CD4 cells in rats.

Methods: A total of 21 male albino rats weighing 100±10g were used for the study. The exercise pre-conditioning was in the form of mere swimming. Serum cortisol was evaluated using Enzyme Linked

Immunosorbent Assay. CD4 cell counts were estimated using Partec Cyflow counter, Germany for the quantification of CD4 T lymphocytes.

Result: It was observed that, there was a significant decrease (P < 0.05) in the serum cortisol level in Group 2 when compared with Group 1 and Group 3, while there was a significant increase (P < 0.05) in the CD4 cell count in Group 2 when compared with Group 1 and Group 3.

Conclusion: Solitary confinement and strenuous exercise were inhibitory to the proliferation of CD4 cells with the elevation of cortisol being a possible mediator.

 

Keywords: Stress, Cortisol, CD4, Swimming.