African Journal of
Cellular Pathology

OFFICIAL PUBLICATION OF THE SOCIETY FOR CELLULAR PATHOLOGY SCIENTISTS OF NIGERIA
  • Abbreviation: Afr. J. Cell. Path
  • Language: English
  • ISSN: 2449-0776
  • DOI: 10.5897/AJCPath
  • Start Year: 2013
  • Published Articles: 64

Evaluation of serum proteins in some immunocompromised patients in Auchi, Edo State, Nigeria

Okogun G R A
  • Okogun G R A
  • Department of Medical Laboratory Science, Parasitology and Entomology Unit, Ambrose Alli University, Ekpoma, Edo State, Nigeria
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Jemikalajah D J
  • Jemikalajah D J
  • Department of Medical Microbiology and Parasitology, Delta State University, Abraka, Delta State, Nigeria
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Adu M E
Saliu R
  • Saliu R
  • Department of Medical Laboratory Science, Ambrose Alli University, Ekpoma, Edo State, Nigeria
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  •  Received: 01 May 2015
  •  Accepted: 01 June 2015
  •  Published: 30 June 2015

Abstract

Aim: Immuno compromised state is a condition of alteration in the immune status of an individual, thereby promoting progression of a disease. This work investigated serum proteins in immuno compromised individuals.

Methods: 5ml venous blood was collected from 120 volunteers which comprised 20 tuberculosis patients, 40 Human immunodeficiency virus patients, 40 pregnant women and 20 age –sex matched apparently healthy individual as controls in Central Hospital Auchi, Edo State. Standard colorimetric method was used to determine the serum total protein, albumin, and globulin as well as albumin/globulin ratio.

Results: A significant increase in total proteins, albumin, and globulins as well as albumin/globulin ratio of Tuberculosis and HIV patients but decrease in pregnant women when compared with control subjects was observed.

Conclusion: Serum protein is a significant diagnostic index in the management of immune-compromised patients.

Keywords: Immuno-compromised, HIV, Tuberculosis, Pregnancy