African Journal of
Cellular Pathology

OFFICIAL PUBLICATION OF THE SOCIETY FOR CELLULAR PATHOLOGY SCIENTISTS OF NIGERIA
  • Abbreviation: Afr. J. Cell. Path
  • Language: English
  • ISSN: 2449-0776
  • DOI: 10.5897/AJCPath
  • Start Year: 2013
  • Published Articles: 65

Full Length Research Paper

Ascorbic acid and testosterone efficacy in spermatoxic and histomorphological changes in Corpora cavernosa in priapism induced sprague-dawley rats

Igwe O.
  • Igwe O.
  • Department of Human Anatomy, Faculty of Basic Medical Sciences, Bingham University Karu, Nasarawa State, Nigeria
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Aniah J. A.
  • Aniah J. A.
  • Department of Human Anatomy, Faculty of Medicine University of Abuja, Federal capital territory Abuja, Nigeria.
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Godam E. T.
  • Godam E. T.
  • Department of Human Anatomy, Faculty of Basic Medical Sciences, Bingham University Karu, Nasarawa State, Nigeria
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Yama O. E.
  • Yama O. E.
  • Department of Human Anatomy, Faculty of Basic Medical Sciences, Kaduna State University, Kaduna, Nigeria.
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  •  Received: 31 July 2017
  •  Published: 31 August 2017

Abstract

Aim: The histomorphological changes in the corpora cavernosa following priapism remains an interesting observation due to its pathological and reproductive implications. We investigated the attenuating effect of testosterone and vitamin C on the corpora cavernosa induced fibrosis in priapism of rats. Methods: Twenty-five Sprague – Dawley male rats were randomly allocated into 5 groups of rats each Group 1 served as the control. Group 2 had only priapism. Group 3 was induced with priapism and then treated with vitamin C. Group 4 was induced with priapism and then treated with testosterone. Group 5 was induced with priapism but were treated with both vitamin C and testosterone. Priapism was induced for one week followed by 6 hours’ post priapism administration of testosterone and vitamin C. Results: Results showed fibrotic corpora cavernosa in all groups except the control group. Sperm parameters indicated oligospermia and reduced sperm motility especially in group 2 and 3 when compared with the control group. Conclusion: The results indicated that testosterone and vitamin C ameliorated priapism-induced ischemia – reperfusion injury at different time intervals in rats.

 

Key words: Priapism, Corpora cavernosa, Infertility, Testosterone, Vitamin C.