Aim: This study aims at the estimation of serum alkaline phosphatase (ALP), alanine aminotransferase (ALT), aspartate aminotransferase (AST), gamma glutmyl transferase (GGT) in Human immunodeficiency virus (HIV) and/or Acquired immune deficiency syndrome (AIDS) patients in parts of Edo State, Nigeria.

Methods: A total of 50 HIV/AIDS positive patients and 50 HIV/AIDS negative subjects as control were studied from January to September, 2014. The enzymes were assayed using standard biochemical methods.

Results: The mean ±SD of alkaline phosphatise for HIV/AIDS patients was significantly increased (p<0.005) when compared with the control subjects. There was no significant increase (p>0.05) in the mean ±SD of ALP, AST, GGT and CD4 of female HIV/AIDS positive patients when compared with male subjects. Also, there was no significant increase (p>0.05) in the mean ±SD of ALT, AST and GGT of male HIV/AIDS positive patients when compared with male control subjects. There was a significant increase (P<0.05) in the mean ±SD of ALP of male HIV/AIDS positive when compared to male control subjects. There was a significant increase (p<0.05) in the mean ±SD of ALP and ALT of female HIV/AIDS positive when compared with female control subjects.

Conclusion: This study has suggested that specific estimation of ALP and ALT should be carried out on HIV/AIDS patients before any kind of treatment.

 

Key: Assessment, Liver, Enzymes, HIV/AIDS