African Journal of
Cellular Pathology

OFFICIAL PUBLICATION OF THE SOCIETY FOR CELLULAR PATHOLOGY SCIENTISTS OF NIGERIA
  • Abbreviation: Afr. J. Cell. Path
  • Language: English
  • ISSN: 2449-0776
  • DOI: 10.5897/AJCPath
  • Start Year: 2013
  • Published Articles: 64

Evaluation of serum proteins in pulmonary tuberculosis

Jemikalajah JD
  • Jemikalajah JD
  • Department of Medical Microbiology and Paraistology, Delta State University, Abraka Delta State
  • Google Scholar
Okogun GRA
  • Okogun GRA
  • Department of Medical Laboratory Science, Parasitology and Entomology Unit, Ambrose Alli University, Ekpoma, Edo State
  • Google Scholar
Adu ME
  • Adu ME
  • Department of Medical Laboratory Services, Antiretroviral Therapy Centre, Central Hospital, Agbor, Delta State
  • Google Scholar
Okolie GC
  • Okolie GC
  • Department of Medical Laboratory Science, College of Health Technology, Ofuoma – Ughelli, Delta State
  • Google Scholar


  •  Received: 01 October 2014
  •  Accepted: 01 November 2014
  •  Published: 30 November 2014

Abstract

Aim: Tuberculosis (TB) remains a major public health problem throughout the world, especially in developing countries with its attendant mortality and morbidity. Proteins in plasma or serum are readily accessible and can be analyzed directly to produce diagnostic information on disease states in patients.

Methods: 5ml of venous blood was collected from One hundred (100) volunteers which comprised fifty (50) pulmonary tuberculosis patients and fifty (50) age – sex matched apparently healthy subjects as controls. The levels of total proteins, albumin, globulins and albumin/globulin ratio were determined in pulmonary tuberculosis patients.

Results: Our results show significantly increased total protein, albumin and globulins in pulmonary tuberculosis patients when compared with controls but no significant difference was observed in the albumin/globulin ratio. There was gender difference in globulin levels.

Conclusion: The study has heightened the imperative of serum proteins assay in the management of pulmonary tuberculosis. Keywords: Pulmonary tuberculosis, Total proteins, Albumin, Globulins.

Keywords: Pulmonary tuberculosis, Total proteins, Albumin, Globulins.