April 2016

COMPARATIVE EVALUATION OF THE EFFECTS OF PALM BUNCH ASH AND TRONA ON THE LIVER OF ALBINO RATS

Aim: To evaluate the haematological, biochemical and histological effects of palm bunch ash (PBA) and trona when used as tenderizers. Methods: Thirty male albino rats were randomly grouped into five designated 1(control), 2, 3, 4 and 5, and were orally given 2 ml of distilled water, 486 mg/kg of trona, 972 mg/kg of Trona, 486 mg/kg of PBA, 972 mg/kg of PBA, respectively for 21 days. Results: The study showed...

Author(s): Okoye JO, Oranefo NO, and Okoli AN  

April 2016

SKELETAL MUSCLE MITOCHONDRIAL ALTERATIONS IN CARBOXYL TERMINUS OF HSC70 INTERACTING PROTEIN (CHIP)-/- MICE

Aim: Hereditary ataxias are characterized by a slowly progressive loss of gait, hand, speech, and eye coordination and cerebellar atrophy. A subset of these, including hypogonadism, are inherited as autosomal recessive traits involving coding mutations of genes involved in ubiquitination including RNF216, OTUD4, and STUB1. Cerebellar CHIPopathy (MIM 615768) is a form of autosomal recessive spinocerebellar ataxia...

Author(s): Jonathan C. Schisler, Cam Patterson, Monte S. Willis