African Journal of
Cellular Pathology

OFFICIAL PUBLICATION OF THE SOCIETY FOR CELLULAR PATHOLOGY SCIENTISTS OF NIGERIA
  • Abbreviation: Afr. J. Cell. Path
  • Language: English
  • ISSN: 2449-0776
  • DOI: 10.5897/AJCPath
  • Start Year: 2013
  • Published Articles: 80

COMPARATIVE EVALUATION OF THE EFFECTS OF PALM BUNCH ASH AND TRONA ON THE LIVER OF ALBINO RATS

Okoye JO
  • Okoye JO
  • Histopathology Unit, Medical Laboratory Science Department, School of Public and Allied Health, Babcock University, Ilishan-Remo, Ogun State, Nigeria
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Oranefo NO
  • Oranefo NO
  • Department of Medical Laboratory Science, Faculty of Health Sciences, Madonna University, Elele Campus, Rivers State Nigeria
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Okoli AN
  • Okoli AN
  • Department of Crop Science and Technology, Federal University of Technology, Owerri, Imo State, Nigeria
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  • Article Number - 4C7993365696
  • Vol.6(4), pp. 21-27 , April 2016
  •  Received: 23 January 2016
  •  Accepted: 10 March 2016
  •  Published: 30 April 2016

Abstract

Aim: To evaluate the haematological, biochemical and histological effects of palm bunch ash (PBA) and trona when used as tenderizers.

Methods: Thirty male albino rats were randomly grouped into five designated 1(control), 2, 3, 4 and 5, and were orally given 2 ml of distilled water, 486 mg/kg of trona, 972 mg/kg of Trona, 486 mg/kg of PBA, 972 mg/kg of PBA, respectively for 21 days.

Results: The study showed decreased body and liver weights (195.00 ± 20.50 to 152.80 ± 27.81{p<0.05} and 9.13 ± 1.28 to 7.38 ± 1.59 {p>0.05}, respectively) and higher relative weight (4.68 ± 0.98 to 4.83 ± 0.34 {p>0.05}) and serum levels of alkaline phosphatase (165.83 ± 16.73 to 349.67 ± 201.99 {p>0.05}). Significant differences in lactate dehydrogenase activity (p<0.05) and insignificant differences in the estimated haemoglobin, packed cell volume, serum amylase and transaminases were also observed (p>0.05). Liver microscopy in the test groups revealed evidences of hepatitis and cholestasis.

Conclusion: this study suggests that both trona and PBA are more toxic at 972 mg/kg but less toxic at 486 mg/kg body weight. Thus, lower concentrations are advised when used as tenderizing agents.

Key words: Trona, Palm bunch ash, Tenderizer, enzymes