African Journal of
Mathematics and Computer Science Research

  • Abbreviation: Afr. J. Math. Comput. Sci. Res.
  • Language: English
  • ISSN: 2006-9731
  • DOI: 10.5897/AJMCSR
  • Start Year: 2008
  • Published Articles: 246

Full Length Research Paper

An automorphism in the LK_ITB5a H110F gene mutation

Qonita Ummi Safitri
  • Qonita Ummi Safitri
  • Mathematics Department, Faculty of Mathematics and Natural Sciences, Institut Teknologi Bandung, Indonesia.
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Elvira Kusniyanti
  • Elvira Kusniyanti
  • Mathematics Department, Faculty of Mathematics and Natural Sciences, Institut Teknologi Bandung, Indonesia.
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Irawati
  • Irawati
  • Mathematics Department, Faculty of Mathematics and Natural Sciences, Institut Teknologi Bandung, Indonesia.
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Ilma Fauziah Ma'ruf
  • Ilma Fauziah Ma'ruf
  • Biochemistry Reasearch Group, Faculty of Mathematics and Natural Sciences, Institut Teknologi Bandung, Indonesia.
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Akhmaloka
  • Akhmaloka
  • Biochemistry Reasearch Group, Faculty of Mathematics and Natural Sciences, Institut Teknologi Bandung, Indonesia.
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  •  Received: 10 January 2020
  •  Accepted: 20 May 2020
  •  Published: 31 July 2020

Abstract

Sanchez et al. (2005) have shown the structure of vector space genetic code over the Galois field GF(4) which relate to the physicochemical properties of the genetic code on proteins. From this vector space, an automorphism can be constructed to reflect the mutation process in the genetic code. This study investigates a type of transformation in the LK_ITB5a lipase gene mutation. The result of the study shows that there is a transformation matrix from the wild type gene lipase LK_ITB5a to mutant gene lipase LK_ITB5a H110F which is a diagonal matrix with non-zero determinant. This means that the transformation is an automorphism.

Key words: Automorphism, vector space, mutational pathways