Sanchez et al. (2005) have shown the structure of vector space genetic code over the Galois field GF(4) which relate to the physicochemical properties of the genetic code on proteins. From this vector space, an automorphism can be constructed to reflect the mutation process in the genetic code. This study investigates a type of transformation in the LK_ITB5a lipase gene mutation. The result of the study shows that there is a transformation matrix from the wild type gene lipase LK_ITB5a to mutant gene lipase LK_ITB5a H110F which is a diagonal matrix with non-zero determinant. This means that the transformation is an automorphism.
Key words: Automorphism, vector space, mutational pathways
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