Background: The knowledge, attitude, and practice of the health sciences students are crucial for their future monitoring and reporting of adverse drug events as professional responsibility. Aim: To describe the knowledge, attitude, and practice of graduating medicine and pharmacy students in College of Health Sciences, Addis Ababa, Ethiopia Method: This study was based on a cross-sectional study design. Data were collected through a structured and pilot-tested questionnaire. The data was entered and analyzed using SPSS version 20. The descriptive statistics such as frequency, mean, standard deviation, percentages computed and the association between variables were conducted using Chi-square. The p-value of <0.05 was taken statistically significant. Result: A total of 140 students were included in this study. The majority of the participants were medicine students 82(58.6%) and males 84 (60%). Most of the respondents, 106 (75.7%) knew the ADE reporting system and 126 (98.6%) drug safety monitoring is important. However, about half of students 65(46.4%) were not aware of the national ADE reporting system. During clerkships 57 (40.7%) participants encountered at least once ADE, but only 23 (16.4%) of them had reported. Graduating pharmacy students have better knowledge on “pharmacovigilance” (84.5 % Vs 43.9%, p < 0.001) but medicine students were better at reporting the encountered ADE (22.0% Vs 8.6%, p=0.04). Conclusion: The graduating medical interns and pharmacy students have a positive attitude towards ADEs. However, they have a low level of knowledge and practice about voluntary adverse drug events reporting.

Keywords: KAP, ADE, pharmacy students, medical interns, Graduating students