August 2017

Chemotherapeutic efficacy of secnidazole-diminazene aceturate combination therapy in experimental Trypanosoma brucei brucei infection in rats

The chemotherapeutic efficacy of secnidazole-diminazene aceturate (SEC-DA) combination therapy was studied in rats experimentally infected with Trypanosoma brucei brucei with a view of eliminating relapse of infection. Twenty rats grouped into 4 groups (n = 5) were used for the study as follows: uninfected untreated (A), infected untreated (B), infected and treated with diminazene (DA) (3.5 mg/kg) alone intraperitoneum...

Author(s): Ifeanyi G. Eke, Ikenna O. Ezeh, Terry A. Ezeudu, Ukamaka U. Ezeh, Aruh O. Anaga and Patrick A. Onyeyili

August 2017

In-vivo evaluation of analgesic, anti-inflammatory and anti-pyretic activity of aqueous methanolic extract of Jatropha gossypifolia

Many pathological conditions are associated with pain, fever and inflammation. Synthetic drugs available for the treatment of these ailments accompany many unwanted side effect; most prominent of which is the gastric ulcer. Present study was thus aimed at evaluating the analgesic, anti-pyretic and anti-inflammatory potential of aqueous methanolic extract of leaves of plant Jatropha gossypifolia. Anti-inflammatory...

Author(s): Mohsin Ahmad Ghauri, Ghulam Jilany Khan, Sara Khan, Aqeel Javeed, Hafiza Sadaf Naeem and Muhammad Ashraf