A review for selecting medicinal plants commonly used for malaria in Uganda
Article in Press
The menace of current cases of parasite resistance to antimalarial drugs, non availability and accessibility, and the high costs of pharmaceutical products contributes to the high rate of medicinal plants consumption in the treatment of malaria in Uganda. Different ethnobotanical surveys on medicinal plants with antimalarial properties have been conducted across different geographical regions in Uganda in order to identify...
Article in Press
The medicinal plants, which are at the origin of the medical sciences, are gradually passing from the apothecary vials, from the handmade bags of the tradipraticians to the laboratories to provide countless models for the synthesis of new medicines. Today, chemical drugs have replaced most herbal drugs in pharmacies. Empirical knowledge has been overlooked as chemistry progresses. Yet 80% of the world’s population is still...
Evaluation of Anti-inflammatory Activity of Clerodendrum wallichii (Merr.) Leaves
Article in Press
Clerodendrum wallichii Merr. (Family: Verbenaceae) commonly known as Sampulis is native to southern Asia from the Himalayas to Southern China, the Nicobar Islands and northeast into Pakistan. In India, it is mainly found in Sikkim, Tripura, Mizoram, Meghalaya, Assam, Maharashtra and Uttarakhand regions. It is widely used for various ailments in the traditional systems of medicines; most importantly, it is used against...
Article in Press
As general awareness for using herbal drugs in today’s health practice is increasing. The world is endorsing extraordinary increase in the consumption of herbal products. This increase in the demand has lead to consumers dissatisfaction dua to substandard products, making the herbal market risky. There is need to set standard that make evaluation of herbal drug in the formulation of high quality products. Present...
Medicinal importance of garlic and onions on autonomic nervous system
Article in Press
Garlic and onion has been of medicinal value in the treatment of hypertension and it also use by people who wanted to loose weight. This research looks in to the effects of these bulbs on the entire nervous system, mechanism of action , complications of over use. This research highlights the chemistry of the active components in ,these bulbs and it role in regulating body's autonomic functions and other possible...
Article in Press
Cardiovascular disease (CVD) is a leading cause of morbidity and mortality. In the gulf countries specially in Saudi Arabia Diabetes type 2 is becoming the highest in the world, affecting around 30% of adults. In fact, diabetes is associated with an increased risk of cardiovascular disease (CVD). The management of diabetic dyslipidemia, a well-recognized and modifiable risk factor, is therefore a key factor in the...
Article in Press
Neuroinflammation, oxido-nitrosative stress and altered levels of neurotrophin are responsible for pathogenesis of anxiety and depressive illness. Polyherbal formulation (PHF) contains extracts of garmarogor, devdaru, shankhavali, pitapapapdo, brahmi, jatamansi, nagarmoth, kadu, tagar, himaj, draksha, ashwagandha. These plants are a rich source of alkaloids, flavonoids, tannins, terpenoids, phenolics and known for...
Pharmacological activities of Ballota saxatilis Sieber ex C. Presl.: A short review
Article in Press
The genera Ballota (Lamiaceae family) distributed mainly in the Mediterranean area, Middle East, and North Africa. From ancient times, various species of this genera are used in traditional medicine for their biological properties such as anti-inflammatory, antimicrobial, antispasmodic, anti-malaria, insecticidal, etc. Various phytochemical investigations identified a large number of flavonoids and other metabolites and...
Adherence to antiretroviral therapy in Kuyyu Hospital, North Shoa, Oromia region, Ethiopia
Article in Press
Good adherence to antiretroviral therapy is necessary to achieve the best virological response, lower the risk of drug resistance, and reduce morbidity and mortality. High levels of adherence (> 95%) are required for ART to be effective for long term and to prevent the emergence of resistant viral strains. The objective of this study was to assess the adherence to ART among patients on ART at Kuyyu Hospital. A cross...
Article in Press
The emergence and dissemination of extended spectrum beta-lactamase (ESBL)-producing Gram-negative bacteria is worrisome as this poses a serious threat in patient management, especially among children and the elderly. The cardinal objective of this study was to determine the antibiogram and prevalence of ESBL-producing E. coli and Klebsiella species among paediatric patients in three different healthcare institutions in...
Article in Press
The objective of the study was to design a fast-dissolving film of cetirizine hydrochloride (CTZHCl) by the solvent casting method using various film-forming polymers like Hydroxyl propyl methylcellulose (HPMC K4M), Polyvinyl alcohol (PVA), Sodium alginate (Na-alg). Six different formulations were designed by varying the concentration of film-forming polymer. Acquired formulations were subjected to various physicochemical,...
Article in Press
Background: Over a decade, different stakeholders have been concerted efforts to reduce morbidity and mortality related to asthma. Despite all these efforts, substantial proportions of asthmatic patients do not achieve proper asthma control. Objective: The aim of this study was to evaluate the level of asthma control and to assess the factors that might influence control of the disease. Settings: The study was conducted...
Article in Press
Pomegranate (Punica granatum L.) is a well-known and widely used fruit, which contains several interesting bioactive compounds and possess health-promoting properties. Seeing the importance of this fruit, it was essential to study its quality characteristics. Hence, in the current study, we assessed total phenolic content, flavonoid content and antioxidant activity of different plant parts (leaves, rind and arils) of two...
Article in Press
Epilepsy, once thought to be a disease of evil spirit, is now believed by many as a common neurologic condition that can be effectively treated by optimal use of anti seizure drugs. Despite the availability of multiple and cost effective medications, people with epilepsy could experience episodes of seizures. Aim of the present study was to assess the treatment outcome and associated factors among adult epileptic patients...
Anti-proliferative and apoptosis induction activities of curcumin on Leishmania major
Article in Press
Leishmaniasis is a major vector-borne disease caused by an obligate intramacrophage protozoan of the genus Leishmania and transmitted by the bite of phlebotomine female sand flies. The parasite causes a wide range of human diseases ranging from the localized self-healing cutaneous lesions to fatal visceral infections. The objective of this study is to investigate the cytotoxic, anti-proliferative, and apoptotic effects of...
Article in Press
Some Malaysian plants were extracted using 80% methanol and screened for antioxidant and toxicity effects on human neuroblastomacells line (SH-SY5Y cells) and zebrafish(Daniorerio) embryos. Antioxidant assay shows high activities with of IC50 1–100 µg/mL with Melastoma malabathricum (leaf and stem), Murraya koenigii (leaf), Curcuma longa (leaf and rhizome), Ficus deltoidea (leaf), Phaleria macrocarpa (leaf) and Ginkgo...
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Base on the findings from the Research Institute Against Counterfeit drugs (RIACD) and the Organization for Economic Cooperation and Development Drugs (OECD), 700,000 cases of death are recorded per year due to malaria and tuberculosis counterfeit drugs. According to the World Health Organization (WHO), roadside drugs kill at least 100,000 people in Africa every year, 1/3 of these drugs are counterfeit. The objective of...
Article in Press
Antioxidants from plants origin are considered as a promising source of biologically active substances when compared to synthetic agents who are accompanied with a number of side effects. Three botanical extracts of Acorus calamus (sweet flag), Prunus persica (peach) and Sausskurea lappa (kuth) were characterized for their antioxidant properties. Methanolic extract was prepared and concentrated by rotary evaporated. The...
Article in Press
A 23 factorial experimental design was used to study the effects of polymer type (A), the nature of the organic phase (B) and the homogenization speed (C) on the particle sizes (S), the amount of drug entrapped (E) and the in-vitro release properties of the formulations (R). Objective This study was aimed to quantify the effects of three production variables on the physicochemical and cytotoxic activities of...
FORMULATION, OPTIMIZATION AND CHARACTERIZATION OF NANOCRYSTALS OF AN ANTIBIOTIC
Article in Press
Nitrofurantoin is a broad-spectrum bactericidal antibiotic which affect both Gram-negative and Gram-positive bacteria. Nitrofurantoin exhibits bacteriostatic or bactericidal effects by inhibiting the synthesis of DNA, RNA, protein and cell wall synthesis. Nanocrystals of NFT were prepared by Cold High Pressure Homogenization technique. NFT was dispersed in aqueous surfactant solution containing Poloxamer 188, PVPK 30 and...
Article in Press
Objective: To obtain optimum and validated method for simultaneous analysis of cyclophosphamide and 4-hydroxycyclophosphamide in Dried Blood Spot using Ultra High Performance Liquid Chromatography Tandem Mass Spectrometry and its application in breast cancer patients for therapeutic drug monitoring. Methods: The separation was conducted using 1.7 μm (2.1 x 100 mm) Waters AcquityTM UPLC C18 column, mobile phase consists of...
Article in Press
Surgical antibiotic prophylaxis (SAP) administration before surgery is evidence-based practice for prevention of Surgical site infections (SSIs). The aim of study was to investigate the pattern of surgical procedures and appropriate use of SAP in teaching hospital of Islamabad, Pakistan. A one-month prospective, descriptive observational pilot study. A total of 235 surgical procedures were investigated during study period...
The Use of Liposomes in Clinical Applications
Article in Press
Liposomes were investigated for a long time as nanocarriers to target drugs to their sites of actions and to reduce toxicity. The unique structure of liposomes which is similar to the cellular phospholipids is considered as being an advantage to such delivery systems. Both hydrophilic and hydrophobic drugs can be encapsulated into the liposomes for delivery of a wide range of drugs such as anticancer drugs and...
Article in Press
Malaria, caused by apicomplexan parasite, is an old disease and continues to be a major public health threat in many countries. This article aims to present different aspects of malaria including causes, pathogenesis, prevention and treatment in an articulate and comprehensive manner. Six Plasmodium species are recognized as the etiology of human malaria, of which Plasmodium falciparum is popular in East and Southern...
Article in Press
Trypanosomiasis is an important protozoan disease affecting domestic livestock production in sub-Saharan Africa. Control of trypanosomiasis is by administration of antitrypanosomal drugs. Quinapyramine was widely used between 1950s and 1970s in Africa as a therapeutic and prophylactic agent in cattle. Trypanosome resistance to the drug developed rapidly and often associated with problems of toxicity. Administration of...
Article in Press
Multidrug-Resistance Tuberculosis (MDR-TB) is tuberculosis (TB) that is resistant to two first-line drugs; both isoniazid and rifampicin. Globally in 2015, there were an estimated 480, 000 new cases of multidrug-resistant TB. According to the anti-tuberculosis drug resistance survey conducted nationwide in Ethiopia in 2012 among 804 newly diagnosed TB cases 1.6 % were found to be infected with MDR-TB. The continuous...
Article in Press
Metabotropic glutamate receptor subtype 5 (mGluR5) is involved in the transition of alcohol use to addiction by activating signalling pathways and inducing glutamate excitotoxicity. The objective was to investigate the effects of chronic alcohol treatment and withdrawal on mGluR5 binding in the brains of C57BL/6J mice. The study was a controlled experiment in which male C57Bl/6J mice were introduced to the alcohol liquid...
Prokinetic effect of ferulic acid ethyl ester on mice
Article in Press
Gastrointestinal (GI) diseases are public health problem which affects 69% of the world's population. Among the disorders that cause gastrointestinal hypomotility is mainly constipation, but drugs available for the treatment of this disorder come with numerous adverse effects, among them the most common are abdominal pain and cardiotoxic potential. Ferulic acid ethyl ester (FAEE) is a phenylpropanoid widely found in...
Synthesis, antibacterial and anticancer activities of some novel 2-substituted aminothiazoles
Article in Press
Amino group of thiazole moiety (26) was treated with various aromatic aldehydes its gave corresponding Schiff's bases (27-36). These Schiff's bases were reacted with benzyl in the presence of ammonium acetate (NH4OAc) to find corresponding novel 2-substituted aminothiazoles (37-46). Structures of all the newly synthesized compounds were confirmed by IR, 1H NMR, mass spectral data and elemental analysis. The synthesized...
Article in Press
This study evaluated the protective effects of commercial herbal preparation (HP) on acetaminophen (APAP) induced lipid profile aberrations in rats. Twenty four male rats were divided into 6 groups of 4 rats each and treated orally as follows: Group 1 (normal control), group 2 (intoxicated and untreated), group 3 (pre-treated with 100 mg/kg b.w. of silymarin), groups 4, 5 and 6 (pre-treated with 1, 2 and 3 ml/kg b.w. HP)...
Article in Press
The limitations of currently available drugs and emergence of multidrug and extensively drug-resistant strains of Mycobacterium tuberculosis (Mtb) stress the need of new candidates as antitubercular agents. Different 2,5-dimethyl pyrrole derivatives clubbed with coumarin, naphthyl, furyl, phenyl, fragment of ibuprofen, fragment of diclofenac were synthesized and evaluated for antitubercular activity. The structure of all...
GLUCOSINOLATES: TAME PRECURSORS – POTENT PRODUCTS-A REVIEW
Article in Press
Cruciferous vegetables constitute an important phytochemical that is Glucosinolate, it is an organic anionic compound containing sulphur, nitrogen and a group derived from glucose. Glucosinolates are abundantly present in the members of family Cruiciferae. The enzymes catalysing the hydrolysis of glucosinolates are known as myrosinases. The potentially beneficial activities of glucosinolates and their enzymatic hydrolysis...
Isolation and Antimicrobial Efficacy of Bergenia ciliate Using in vitro Models
Article in Press
Antimicrobial activities of five constituents isolated from ethyl acetate fraction of Bergenia ciliate were investigated. About all constituents exhibited antimicrobial efficacy on the tested microorganisms, including two human Gram-positive bacteria (Staphylococcus aureus, Micrococcus luteus) and four Gram-negative ones (Escherichia coli, Pseudomonas aeruginosa, Enterobacter cloacae, Klebsiella Pneumonia). Of these...
Article in Press
Film forming gels are a novel approach in this area that might present an alternative to the conventional dosage forms used on the skin, such as ointments,creams, gels or patches. The polymeric solution is applied to the skin as a liquid and forms an almost invisible film in situ by solvent evaporation. Transdermal drug delivery system (TDDS) can provide some desirable performances over conventional pharmaceutical dosage...
Article in Press
The use of plants extract in traditional medicine continues to provide the therapeutic needs for greater percentage of the world’s population especially in developing countries. In this study, the phytochemical properties and biochemical responses of some haematological parameters and prostaglandin of gastric lesions to ethanol extract of Jatropha multifida leaves were investigated. The quantitative phytochemical analysis...
Article in Press
The present study has been designed to examine the antimicrobial activity of aqueous and organic extracts of powdered pod, leaves and flowers of an endemic terrestrial orchid Brachycorythis iantha. The extracts of Brachycorythis iantha were tested against the bacterial pathogens via Streptococcus pyogenes, Staphylococcus aureus, Pseudomonas aeruginosa, Proteus vulgaris and fungus (Candida albicans). Antimicrobial...
Nutritional management of diabetes
Article in Press
Diabetes mellitus is a multifaceted unending disease and is a key source of death worldwide. It is responsible for more than a million amputations every year. It is anticipated that 400 million people worldwide will suffer from diabetes by 2030. The likelihood of developing diabetes depends on a blend of genetic factors, obesity, living style and environmental factors. There are two major types of diabetes: insulin...
Article in Press
The ethyl acetate extracts through maceration extraction of stem bark of Glossonema boveanum (Decne.) (Asclepiadaceae) afforded one pentacyclic triterpene, betulinic acid, which is reported for the first time in this plant. The structure of the isolated compound was identified on the basis of 1D NMR (1H, 13C and DEPT), 2D NMR (COSY, HSQC, HMBC and NOESY) and by comparison with reported data. The isolated compound was then...
Article in Press
Conventional chemotherapy for the treatment of intracellular infections is not effective, due to limited permeation of drugs into cells. This can be overcome by use of vesicular drug delivery systems. Encapsulation of a drug in vesicular structures can be predicted to prolong the existence of the drug in systemic circulation, and perhaps, reduces the toxicity if selective uptake can be achieved. Proniosomes are dry powder...
Neutrophil-to-lymphocyte ratio of fixed dose highly active antiretroviral drugs using white rabbit
Article in Press
There is an increasing reliance on neutrophil-to-lymphocyte ratio (NLR) as a prognostic marker in certain diseases. Observations have suggested the effects of administering highly active antiretroviral therapy (HAART) to human immunodeficiency virus (HIV) patients to be beneficial as well as having its side effects. Hence, this study was designed to examine the relationship of NLR of fixed dose HAART. Twenty male white...
Article in Press
Brands are considered as one of the most valuable assets of companies in the area of ever increasing competitions of markets, goods and various services. Physicians are actually the ultimate decision holder of which brand should be prescribed to their patients. Prescribing behavior of physicians affected by many factors. The present study investigates the factors which influence physician prescribing decisions. In order to...
Article in Press
The need to consider an ethnomedicinal alternative for the management of hypertension has become necessary due to the high cost associated with purchasing conventional antihypertensive drugs and the inability of patients to adhere strictly to the procedures of administration. A total of 40 acclimatized male Wistar rats were used for the study. Five rats were grouped as normotensive control (group A). 25 hypertensive rats...
Evaluation of analgesic activity of the ethanolic extract of Pennisetum purpureum in albino mice
Article in Press
Pennisetum purpureum (Elephant or Napier grass) is being used in East Africa and some other parts of the world as animal feed and also in pulp industry. In some parts of South eastern Nigeria where it is popularly known as ‘’Achara‘’ it is a delicacy in some traditional dishes. In recent studies, its nutritional and non-nutritional components reveal that it contains flavoids, saponin, sterols, glycosides, tannins and high...
Article in Press
Repositioning of drug using pharmacovigilance approach is the primary objective of this study. Rosiglitazone is the target molecule for this pilot scale study. Rosiglitazone is an anti-diabetic drug of thiazolidinedione class. It works as an insulin sensitizer, by binding to the peroxisome proliferator activated receptor (PPAR) gamma in fat cells and making the cells more responsive to insulin. Rosiglitazone has been...
Analgesic properties of snake venom as compared to conventional analgesics
Article in Press
An analgesic is a drug that relieves pain by acting on the central nervous system or peripheral pain receptor mechanisms; while snake venom is a highly modified saliva containing zootoxins which facilitate the immobilization and digestion of prey and defense against threats. Snake venom is toxic but may also have therapeutic effects, e.g. captopril, an Angiotensin-Converting Enzyme inhibitor was developed from the Pit...
Article in Press
This research was designed to develop and validate a precise, simple, rapid, reliable, more accurate, as well as least time consuming High-Performance Liquid Chromatography (HPLC) technique for simultaneous and individual estimation of atorvastatin, rosuvastatin and simvastatin in whole and in various formulations. This separation was attained chromatographically using blend of methanol and trifluroacetic acid (0.1%) in...
Article in Press
Nowadays, the growing interest in consumption of fruit and vegetables raises the question of cooking impact on their nutritional benefits. Growing evidence suggests that oxidative damage caused by the β-amyloid peptide in the pathogenesis of Alzheimer’s disease may be hydrogen peroxide mediated. Many polyphenols, the most abundant dietary antioxidants, possess stronger neuroprotection against hydrogen peroxide.The...
Scientific and technological prospect of Platonia insignis Mart (Clusiaceae)
Article in Press
The chemodiversity and pharmacological potential of the flora are uncounted and allow the study of native plants, such as Platonia insignis Mart. (Clusiaceae), an exotic plant in Piaui, Brazil. Investigations on the chemical composition of the plant of the family Clusiaceae have shown that they are mainly rich in polysoprenylated benzophenones and xanthones, which have been isolated not only from the resins, but also from...
Article in Press
The prophylactic effect of ethanolic leaf extract of Nauclea latifolia, widely used in herbal malarial treatment, against the widely used drug Coartem® (Artemether/Lumefantrine) in Plasmodium-infected mice was investigated, and thereafter analysed for organosomatic index, parasitemia, histomorphological and immunohistochemical changes in the hippocampus. Twenty male mice about 6 to 8 weeks weighing 20 to 24 g were...
Article in Press
The dipeptidyl peptidase-4 (DPP-4) inhibitors are a new class of anti hyperglycemic agents which were developed for the treatment of type-2 diabetes mellitus by rational drug design, based on an understanding of the mechanism of action and knowledge of the structure of the target enzyme. Glucagon-like peptide-1 (GLP 1) and gastric inhibitory polypeptide (GIP) are hormones secreted by the enteroendocrine cells of the gut in...
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