African Journal of
Pharmacy and Pharmacology

  • Abbreviation: Afr. J. Pharm. Pharmacol.
  • Language: English
  • ISSN: 1996-0816
  • DOI: 10.5897/AJPP
  • Start Year: 2007

AJPP Articles in press

Clinical and Parasitological evaluation of cutaneal lesions in Mesocricetus auratus infected with Leishmania amazonensis

Article in Press

Cutaneous leishmaniasis is an infectious-parasitic disease that is vector-transmitted by female Phlebotomus species through a blood meal. The drugs recommended by the Ministry of Health show moderate efficacy and numerous adverse reactions, making it necessary to develop new drugs. However, it is essential to establish new and vibrant diagnostic techniques detecting and quantifying the parasites in experimental animals in...

Author(s):Bruno Bezerra Jensen, Claudia Dantas Comandolli-Wyrepkowski, José Fernando Marques Barcellos, Aline Fagundes da Silva, Paula Figliuolo da Cruz Borges, Rebecca Sayuri Barbosa Hanada, Francimeire Gomes Pinheiro and Antonia Maria Ramos Franco

Effect of flavonol from chamomile (Matricaria recutita) flavonoids on memory disorders and determination of oxidative stress in Alzheimer's rats

Article in Press

Alzheimer's disease is one of the most common neurodegenerative diseases. Beta-amyloid plaques and neurofibrillary tangles are two important factors in Alzheimer's disease. Many cellular changes, such as oxidative stress, neuronal inflammation, and mitochondrial disorders are also seen in Alzheimer's disease, which lead to neuronal death. The flavonol in the chamomile plant (Matricaria recutita) have great effects on...

Author(s):Seyed Reza Pourrabie

Evaluation and validation of Limited Sampling Strategy for estimating individual exposure of Mycophenolic Acid in renal transplant children receiving concomitant Tacrolimus

Article in Press

Limited sampling strategies (LSS) for estimating the area under the concentration time curve (AUC) of mycophenolic acid (MPA) in renal transplant children receiving concomitant tacrolimus have been developed, but not yet fully validated. The objectives of the present study were to evaluate the predictive performance of previously published LSS of MPA in an independent paediatric population, and validate a reliable and...

Author(s):BROU Nguessan Aimé , TE BONLE Leynouin Franck-olivier, BALAYSSAC Eric , N’ZOUE Kanga Sita and SANGBEU Bertrand

Impact of Artemisia annua and Moringa oleifera on Viral Load, T Cell Activation, and Exhaustion in Ugandan PLWH

Article in Press

HAART effectively controls HIV replication in HIV-positive individuals, but chronic immune activation persists, leading to increased virus replication, T cell depletion, and exhaustion, necessitating lifelong HAART to prevent disease progression. This study explores the potential of supplementing HAART with Artemisia annua and Moringa oleifera leaf powders as adjuvants to restore immune function and control viral...

Author(s):Silvano S. Twinomujuni, Patrick E. Ogwang, Esther C. Atukunda, Phillip Ssekamatte, Diana Sitenda, Rose Nabatanzi, Martin Amanya, Hussain Y. Ungo-kore, Felicitas Roelofsen, Bannet Asingura, Bernard S. Bagaya and Joel Bazira

Pharmacovigilance and adverse drug reporting amongst pharmacy students in southeastern Nigeria; A cross sectional study

Article in Press

Globally, adverse drug reactions (ADR) are underreported, but more so in developing nations where fewer medical professionals participate. There is currently no literature on the knowledge of ADR reporting among pharmacy students in southeastern Nigeria. To determine pharmacy students' understanding and attitudes about pharmacovigilance and reporting of adverse drug reactions. The study was a cross-sectional study...

Author(s):Ozota, Gerald Obinna, Eze, Kingsley Chinemerem, Eze, Shadrach Chinecherem, Anyaji, Ugomma Loveth, Arugo, Wisdom Enyinnaya, Odoh, Evaristus Chinonso, Ijegalu, Kenedy Onyedikachi, Igwenagu Henry Chiagozie, Okolie, Hilda Nkechi, Uzoma, Mmesoma Peace, Orisakwe, Favour Oluchukwu, Ogbonna, Emmanuella Tochukwu

Optimizing tacrolimus therapeutic drug monitoring in Tunisian kidney transplant recipients: exploring the variability in bioavailability and the correlation between pharmacokinetic parameters.

Article in Press

While the existing literature extensively covers the topic of tacrolimus variability, it remains crucial to gather data that are tailored to the Tunisian population. Our primary goal was to assess the variability in tacrolimus bioavailability using the Cp(0)/weight dosage ratio in Tunisian kidney transplant patients. We also aimed to determine the correlations between blood trough level (Cp(0)) and the area under the...

Author(s):Ghaith Aloui, Pharm.D, Rym Charfi, M.D, Mouna Daldoul, M.D, Syrine Ben Hammamia, M.D, Mouna Ben Sassi, M.D, Mohamed Zouari, Hanene ElJeberi, Ph.D, Ph.D, Riadh Daghfous, M.D, Emna Gaies, M.D, Sameh Trabesli, M.D

Effects of the use of piper betle l. leaf extract associated with adipose-derived stem cells on ulcers in streptozotocin-induced diabetic mice

Article in Press

Diabetic ulcers are hard or unable to heal or heal without the restoration of the function. Piper betle L. is known as a valuable traditional medicine to cure open wounds through its antibacterial, anti-inflammatory capabilities and the stimulation of fibroblast proliferation. In addition, adipose-derived stem cells (ADSCs) are able to renew themselves and differentiate into many cell types when repairing the wounded...

Author(s):Van Huong Nguyen, Pham Phuoc Hung Lam, Thi Minh Thu Ngo and Ngo Hieu Nguyen

Antioxidant and Antibiofilm activity of Ageratum conyzoides L, and Bidens pilosa L against wound pathogens

Article in Press

Biofilms infections are a huge concern in the medical field due to increased antibiotic resistance. Plants may be a potential solution because they possess a variety of phytochemicals that have several biological activities. They also act as antioxidants an important property in preventing biofilm formation in wounds. This study aims to investigate the antioxidant and antibiofilm potential of Ageratum conyzoides L, and...

Author(s):Catherine Namuga, Haruna Muwonge, Moses Solomon Agwanya and Johnbaptist Kirabira

Antihyperglycemic and Pancreatic ?-Cells Protective Effects of Cassia siamea in Alloxan-Induced Diabetic Wistar Rats

Article in Press

Previous studies have shown that leaves of Cassia siamea (Fabaceae) exhibited benefic effects in experimental diabetes models. This study aimed to investigate ?-Cells protective effects of ethanol extracts of the leaves of C. siamea (LECS). First, acute toxicity of LECS (2000 mg/kg/day/bw; po) in rats. In vitro, its antioxidant activity was evaluated on HUVECs culture. Second, acute hypoglycemic and antihyperglycemic...

Author(s):Camille KOFFI, N’goran Mathieu KOUAME, Kouassi Eugène KOFFI, Kanga Sita N’ZOUÉ, N’guessan Alain Roland YAO, Brahima DOUKOURE and Mamadou KAMAGATE

Evaluation of the binding property of sesamum radiatum (PEDALIACEAE) extract by wet granulation method in comparison to standard gelatin in the formulation of metronidazole tablet

Article in Press

This research was designed to study the potentials of Sesamum radiatum, a natural gum for use as a tablet binder in metronidazole tablet formulation by wet granulation method. The S. radiatum was extracted from the dried leaves weighing 500g, it was soaked in hot distilled water for 3 hours and extracted through a calico cloth. The solution obtained was precipitated with acetone in a ratio of 1:1, dried on a tray for 2...

Author(s):Sheik Muhammad

Antiplasmodial Activities of selected Artemisinin-Based Combination Therapy (ACT) Drugs co-administered with Beer in Plasmodium berghei-infected Albino Rats.

Article in Press

Alcoholic beverages, particularly beer, are widely consumed in Nigeria despite its contribution to most disability, deaths, and some non-communicable diseases. Based on unpublished reports, some individuals consume alcoholic beverages while treating malaria, which raises concerns about potential interactions between alcohol and antimalaria drugs. However, there is paucity of information on the effect of alcoholic beverage...

Author(s):Olajoju Temidayo Soniran, Segun Solomon Ogundapo and Joseph Bagi Suleiman

Assessment of the in vivo acute toxicity of aqueous extracts of artavol® antimalaria herbal tea

Article in Press

Acute toxicity, is one of the important tests conducted for the initial determination of the safety of products and is the effects of single or multiples doses of a product administered to animals or taken by humans within a 24-hour period. It is one important test required for the initial determination of the toxic characteristic of a product destined for use in humans, animals, and in Agriculture. Many herbal Medicinal...

Author(s):Authors: Joseph Oloro, Amon Agaba Ganafa, Oscar Okidi P’okello, James Mbaria Mucunu and Timothy E. Maitho

Quality Assessment of Generic Brands of Enrofloxacin Available on the Ugandan Market

Article in Press

Enrofloxacin is a fluoroquinolone antibiotic with broad-spectrum activity and is widely used for the treatment of various bacterial infections in animals and poultry worldwide. This study intended to evaluate the quality of enrofloxacin brands available in the Ugandan market. Two batches of eight different brands of enrofloxacin were purchased from veterinary pharmacies in Kampala and Mbarara cities. Standard physical and...

Author(s):Richard. L. Maseruka, Mark Juba, Lydia Akello, Edson Ireeta Munanura, Bruhan Kaggwa, Margaret Ndagire, Paul Rubayiza and, John Wasswa

Assessment of Antimicrobial Prescription Pattern and Associated Factors among Pediatric Inpatients in Felege-Hiwot Comprehensive Specialized Hospital, Northwest Ethiopia

Article in Press

The most effective strategy for combating antibiotic resistance is rational antibiotic prescribing. The percentage use of antibiotics has been used as a key indicator to determine whether the use of antibiotics is appropriate or not in pediatric patients. The aim of this study was to assess the use of antibiotics in paediatric inpatients treated at Felege- Hiwot comprehensive specialized hospital. To assess antimicrobial...

Author(s):Wagaw Wondimnew, Mekash Tamrat, Dagnnet Derebe and Mulugeta Mihrete

Social and Environmental Factors Influencing Drug Promotion in Ethiopia

Article in Press

Drug promotion influences physicians in such a way that they have a tendency for irrational prescribing, preference for newer, more expensive drugs and an inability to identify incorrect claims about drug products. Therefore, this study assessed interactions of drug promoters and physicians and its effect on prescribing in Ethiopia. A cross sectional study was conducted among physicians working both in private and public...

Author(s): Teshager Aklilu Yesuf, Birhanu Demeke Workneh, Mengistie Yirsaw Gobezie, Haftom Gebregergs Hailu and Segenet Zewdie Ayele

Studies of Phytochemical Analysis, In vitro and In vivo Evaluation of the local Pseudoelephantopus spicatus Plant

Article in Press

The plant Pseudoelephantopus spicatus is used as folklore medicine in Bangladesh especially in rural side and Chittagong Hill tracts for appeasing many diseases. Methanolic extracts of plant of P. spicatus and its different Kupchan partitionates i.e. CH3OH soluble partition (MESP), n-C6H14 Soluble partition (HSP), CH2Cl2 Soluble partition (DCMSP), Ethyl acetate Soluble partition (EtAcSP) and Aqueous Soluble partition...

Author(s):Md. Hasan Ali, Md. Shariful Islam, Mohammad Mahmudul Hasan, Hasanur Rahman, Forkan Saroar, Mohammad Abdullah Taher and Tanvir Muslim

Characterisation and analysis of prepared fluconazole nanogel for treating seborrheic dermatitis

Article in Press

This study aims to demonstrate antifungal activity and in-vitro analysis of fluconazole nanogel with different polymer concentration for seborrheic dermatitis The class of antifungal drug- Fluconazole was used to formulate the nanogel with different concentrations of polymers. The prepared batches of nanogel were analyzed for its antifungal activity, ex-vivo skin permeation study, and skin thickness study. The animals are...

Author(s):Divya, Inderbir Singh and Upendra Nagaich

Anti-aging herbal cream – a review

Article in Press

In this review, we discuss the plants which having anti-aging, antioxidant properties. With the use following we can prepare a herbal anti-aging cream which use to treat skin conditions such as hyper pigmentation, ageing, dry skin, wrinkles, and discoloration. A large number of antioxidants, these are the substance that help to protect the skin’s surface from oxidative damaged by free radicals. Different types of...

Author(s): Rajeev Kumar

Drug-Related Problem among Heart Failure Patients enrolled to Ambo University Referral Hospital: Prospective Observational Study

Article in Press

A drug related problem is an event or circumstance involving drug therapy that actually or potentially interferes with desired health outcomes. To assess, classify and identify drug related problems among heart failure patients admitted to the medical ward of the Ambo University Referral Hospital. This prospective study included 124 eligible heart failure patients consecutively admitted to the Ambo University Referral...

Author(s):Endalkachew Mekonnen Eticha

Acute toxicity and laxative effect of the aqueous extract of the leaves Crossopteryx febrifuga (Benth) in rats

Article in Press

The leaves of Crossepteryx febrifuga (Euphorbiaceae) are commonly used in the Republic of Congo in traditional medicine as a laxative. The present study aims to justify the traditional use of Crossopteryx febrifuga in the treatment of constipation. The acute toxicity of the aqueous extract was evaluated at the doses of 2000 mg/kg and 5000 mg/kg in mice accordance the OECD, (2001) guideline no. 423. The laxative activity of...

Author(s):Elion Itou RDG, Etou Ossibi AW, Boukongo R.P, Mambeke H.M, ,Morabandza CJ and Abena AA

Antiviral compounds from Jatropha curcas seed extract with anti-HIV-1 and Anti-SARS-CoV-2 action

Article in Press

Although there are studies dealing with the medicinal properties of Jatropha curcas, the scope of its antiviral potential is still quite limited, a fact that, associated with the current challenges posed by HIV-AIDS and COVID-19, reinforce the need to expand the supply. Knowledge about the antiviral resources available to it. In this context and in the search for natural products with anti-HIV-1 and anti-SARS-CoV-2...

Author(s):Elvino José de Sousa Ferrão and Edilson Armando De Germano Janeque

Impact of pH ambiance and Heating to the antioxidant potential of Secang Wood (Caesalpinia sappan L.)

Article in Press

Secang woods (Caesalpinia sappan L.) is well known as ingredients for a variety of Indonesian traditional beverages. Generally served with spices in warm conditions, this can change the properties of the natural ingredient of secang woods and their activity as medicinal potential. The efficacy of concoction drinks has been influenced by changes in pH and temperature during the serving process, so it is necessary to study...

Author(s):Yoga Windhu Wardhana, Yedi Herdiana and Sriwidodo Bardi

Medicine Expiry, Contributing Factors, and disposal practices in selected Public Health Facilities of South Gondar Zone, Amhara Region, Ethiopia: a mixed method study

Article in Press

The high availability of expired medicines is not only a burden to the healthcare system but also indicates the existence of a supply chain gap. To determine the prevalence of expired drugs, contributing factors and disposal practices in the selected public healthcare facilities in the South Gondar Zone, Amhara Regional State, Ethiopia. This was a mixed-method study design, in which the quantitative component preceded the...

Author(s):Getu Tesfaw Addis, Abraham Nigussie and Yohannes Shumet Yimer

Investigation of the optimal immunosuppressive dose of cyclophosphamide in wistar rats (Rattus norvegicus) raised in a pharmacology laboratory in Abidjan, Ivory Coast

Article in Press

A recent experimental study was conducted in a pharmacology laboratory in Abidjan on the immunomodulatory activity of a plant remedy. The dose of cyclophosphamide used to depress the rats in the study at the beginning of the experiment did not give the expected results. The objective of this work was to determine the optimal dose of immunosuppressive cyclophosphamide in wistar rats raised in this laboratory. This was an...

Author(s):Eric Gbongué TIA, Thierry-Lenoir Ayoman DJADJI, Landry Sylvain KOUAKOU and Gisèle N’doua KOUAKOU-SIRANSY

Prevalence of gastric diseases linked to Helicobacter pylori, retrospective study in West region (Dschang city) in Cameroon, from 2008 to 2018 and therapeutic trial based on extracts of Nauclea pobeguinii (Rubiaceae)

Article in Press

The prevalence of various gastric diseases is poorly documented around the world, particularly in Africa and more specifically in Cameroon. Their treatment till today remains an important subject of study. Nauclea pobeguinii is a plant in the Rubiaceae family and is commonly used in traditional medicine to treat illnesses such as fever, gastric ulcer, arthritis, and pain. The present research established the...

Author(s):Madjo Kouam Yacine Karelle, Fagni Zenab Njoya Linda, Matah Marthe Vanessa Mba, Ngoufack Azanze Elvira, Tsafack Eric Gonzal, Djuichou Nguemnang Stephanie Flore, Adjouzem Carine Flore and Ateufack Gilbert

Knowledge, perception and beliefs of human health workers and veterinarians on antimicrobial resistance in Ouagadougou, Burkina Faso

Article in Press

Antimicrobial resistance is a major public health problem in both hospital and community acquired infections. This study assessed knowledge, attitudes and perceptions on antimicrobial resistance among human health workers and veterinarians in Ouagadougou. A cross-sectional study using a self-administered questionnaire was applied among medical health and veterinary structures in Ouagadougou, Burkina Faso on February 2020...

Author(s):Souleymane Soré, Fatimata Bintou Josiane Diarra, Emmanuel Sampo, Sandaogo Hamidou Ouandaogo, Abdoul Salam Ouédraogo, Idrissa Sanou

Determinants and management of cardiac toxicities induced by anthracycline-based regimens in adult patients with cancer at Kenyatta national hospital

Article in Press

Anthracyclines are used in the standard treatment protocols for solid and hematological cancers. Despite their extensive usage, they cause cardiac toxicities. These toxicities require prompt management to reduce the risk of their complications. To investigate the determinants and management strategies of anthracyclines induced cardiotoxicities in adult patients with cancer at Kenyatta National Hospital (KNH). A...

Author(s):Stephen Makori Gichana, Peter N. Karimi, Irene W. Weru and Stanley N Ndwigah

Seroprevalence of IgM and IgG antibodies of contaminated staff in EHUO Hospital detected by RT-PCR during the COVID-19 pandemic

Article in Press

Anti-SARS-CoV-2 serological tests present a major role in the estimation of the prevalence of Covid-19. The objective was to estimate the prevalence of Covid-19 among staff of University Hospital (EHUO) of Oran (Algeria). The study took place between December 2020 and January 2021 in the pharmacovigilance department, in collaboration with the occupational medicine department of the EHU of Oran, a Serological analysis by...

Author(s):A. TACHEMA, F. HAOUATTI, A. SMAIL, H. CHADOU, F. BOUDIA, M. SEDDIKI, A. MEMOU, NFZ. MEKAOUCHE, H. FETATI, R. MEDJANE, H. TOUMI

Medicinal Plants of Solanum Species: Promising sources of phyto-insecticidal compounds

Article in Press

Many insects including mosquitoes are important vectors of deadly pathogens and parasites, which in the world’s growing human and animal populations can cause serious epidemics and pandemics. Plants provide a large library of phytochemicals, which can be used to replace chemically synthesized insecticides, and utilization of herbal product-based insecticides is one of the best and safest alternatives for mosquito control....

Author(s):Kumarappan Chidambaram, Krishnaraju Venkatesan; Taha Alqahtani; Kumar Venkatesan, Afaf Aldahish, Kavitha Dhandapani

Bioactive constituents, hepatoprotective and antioxidant activity of the Sub-fractions of Fadogia cienkowskii leaves Schweinf (Rubiaceae)

Article in Press

Background: Fadogia cienkowskiiis claimed to ethnomedicinally cure general body debility, inflammation, liver diseases, oxidative stress-related diseases, diarrhoea, fever, and other ailments. Aim and Objectives: The purpose of this study is to investigate the hepatoprotective and antioxidant activities of the sub-fractions of Fadogia cienkowskii leaves. The bioactive constituents present in the ethanol extract of...

Author(s):Stella O. Bruce, Felix A. Onyegbule, Ogechi O. Anyanwu, Chioma R. Ezenwelu, Christopher O. Ezugwu

Jianpi Mixture Decreases Inflammatory Response in Diarrhea-Predominant-Irritable Bowel Syndrome through the Inhibition of Protease Activated Receptor 2 Signal

Article in Press

To explore the protective mechanism of Jianpi Mixture on diarrhea-predominant-irritable bowel syndrome mice. Methods. To observe the intestinal protection of Jianpi Mixture on intestinal tract of diarrhea-irritable bowel syndrome mouse model. The method for the content determination of serum immunoglobulin A (IgA), IgG, IgM, interleukins and tumor necrosis factor alpha (TNF?) was ELISA. The mRNA levels of IL-1?, IL-6 and...

Author(s):Guoqiang Liang, Xin Yang, Haifeng Yun, Huiping Zhu, Chuan Zhang, and Hongwen Sun

Knowledge, Attitude and Practice of Community Pharmacy Professionals’ towards Substandard and Falsified Medicines in Addis Ababa, Ethiopia: A Cross-sectional Survey

Article in Press

The availability of substandard and falsified medicines in the market grants a serious public health problem and a significant impact on the national economy. Current estimate suggests 10% of prescription drugs sold worldwide are substandard, fake or contaminated, and in parts of Africa and Asia, the figures exceed 50%. Professionals' awareness towards falsified medicines is a major problem that could lead to...

Author(s):Bezawit Girma, Solomon Getnet Meshesha and Zelalem Tilahun Mekonen

Screening of selected nigerian medicinal plants/seeds for growth inhibitory activity against human leukemia hl-60 cells and dpph radical scavenging activity

Article in Press

Leukemia is the most common cancer in children, accounting for a prominent percentage of cancer-related death in that age-group. It is therefore very important to prevent and treat this cancer. In this study, the anticancer effects of 6 different parts of 4 selected species of medicinal plants in Nigerian, especially those grown in South-Western and South-Eastern regions, were investigated on Human leukemic-HL-60 cell line...

Author(s):Saheed Afolabi, Olalekan Agede, Anoka Njan, Olufunke Olorundare, Mamoru Koketsu

Characterization of Nanoparticle-encapsulation of β-carotene Isolated from Daucus carota

Article in Press

β-carotene is a potent lipophilic nutraceutical which has low bioaccessibility and bioavailability caused by poor water solubility, stability, sensitivity to light, temperature and pH. Nano-encapsulation can protect it from degradation and retain a compound's functional property. The aim of this study is to characterize the β-carotene from Daucus carota root which is nano-encapsulated with the chitosan matrix with TPP....

Author(s):Muhamad Taswin, Azza Hanif Harisna, Dwi Wahyu Nugroho, Putri Hawa Syaifie, Etik Mardliyati, Sonlimar Mangunsong and Satheesh Babu Natarajan

Post-Market Surveillance of Three Brands of Ibuprofen 400 mg Tablets in Gaborone, Botswana

Article in Press

The supply of sub-standard pharmaceutical products is on the rise. This imposes a greater challenge to health, and hence the need to constantly investigate the quality of medicines to check compliance with international official standards; surveillance. The purpose of the study was to compare three distinct brands of commercially available Ibuprofen 400 mg tablets in Gaborone, Botswana to elucidate compliance through...

Author(s):Livesey David Olerile, Unopa Thabo Ishmael, Amuchilani Waniwa, Thato Tabengwa, Patience Tekanyo

Variation of Antioxidant and Antibacterial Activities of Ethanolic Extracts of Propolis in Three Bee-Keeping Agro-Ecological Zones of Uganda

Article in Press

Propolis is a resinous plant material collected by bees to defend their colony. Unlike temperate propolis which is well studied, tropical propolis, particularly from Eastern Africa, remains largely uncharacterized. In this study, the antibacterial and antioxidant activities of Ugandan propolis were evaluated in relation to three bee-keeping agro-ecological zones of the country. Duplicate propolis samples from each...

Author(s):Julius Kyomya, Mariam Kaanyi Kirabo, Wilberforce John Mayoka, Rehema Namunyenga, Rogers Jaggwe, Lawrence Imanirampa, and Jonans Tusiimire,

Quality assessment of frequently available mother tinctures in the market by employing standard values

Article in Press

As general awareness for using herbal drugs in today’s health practice is increasing. The world is endorsing extraordinary increase in the consumption of herbal products. This increase in the demand has lead to consumers dissatisfaction dua to substandard products, making the herbal market risky. There is need to set standard that make evaluation of herbal drug in the formulation of high quality products. Present...

Author(s):Mahrukh Malik and Syeda Aaliya Shehzadi

Medicinal importance of garlic and onions on autonomic nervous system

Article in Press

Garlic and onion has been of medicinal value in the treatment of hypertension and it also use by people who wanted to loose weight. This research looks in to the effects of these bulbs on the entire nervous system, mechanism of action , complications of over use. This research highlights the chemistry of the active components in ,these bulbs and it role in regulating body's autonomic functions and other possible...

Author(s):Kehinde Alare, Taiwo Alare, Nallely Luviano

Examining the adherence of simvastatin prescription in diabetic patients: a descriptive study at hera general hospital makkah (HGH)

Article in Press

Cardiovascular disease (CVD) is a leading cause of morbidity and mortality. In the gulf countries specially in Saudi Arabia Diabetes type 2 is becoming the highest in the world, affecting around 30% of adults. In fact, diabetes is associated with an increased risk of cardiovascular disease (CVD). The management of diabetic dyslipidemia, a well-recognized and modifiable risk factor, is therefore a key factor in the...

Author(s):Majd Alharazi, Nouf Almalki, Hutaf Alhabashi, Rahaf Felemban, Raghad Qasim,Asala Assas, and Yosra Alhindi

Pharmacological activities of Ballota saxatilis Sieber ex C. Presl.: A short review

Article in Press

The genera Ballota (Lamiaceae family) distributed mainly in the Mediterranean area, Middle East, and North Africa. From ancient times, various species of this genera are used in traditional medicine for their biological properties such as anti-inflammatory, antimicrobial, antispasmodic, anti-malaria, insecticidal, etc. Various phytochemical investigations identified a large number of flavonoids and other metabolites and...

Author(s): Sanjay Kumar, Shailja Mishra and Reshma Kumari

Adherence to antiretroviral therapy in Kuyyu Hospital, North Shoa, Oromia region, Ethiopia

Article in Press

Good adherence to antiretroviral therapy is necessary to achieve the best virological response, lower the risk of drug resistance, and reduce morbidity and mortality. High levels of adherence (> 95%) are required for ART to be effective for long term and to prevent the emergence of resistant viral strains. The objective of this study was to assess the adherence to ART among patients on ART at Kuyyu Hospital. A cross...

Author(s):Tamirat Bekele Beressa, Anbessa Bekele

Antibiogram and Prevalence of Extended Spectrum Beta-Lactamase (ESBL)-producing E. coli and Klebsiella Species among Paediatric Patients in Abakaliki, Nigeria

Article in Press

The emergence and dissemination of extended spectrum beta-lactamase (ESBL)-producing Gram-negative bacteria is worrisome as this poses a serious threat in patient management, especially among children and the elderly. The cardinal objective of this study was to determine the antibiogram and prevalence of ESBL-producing E. coli and Klebsiella species among paediatric patients in three different healthcare institutions in...

Author(s):Iroha I. R., Ezeora C. A., Moses I. B., Onuora A. L., Kalu A. C., Ude-Ude I., Nwakaeze A. E., Ugbo E. N., Ngwu J. N., Uzoeto J. O.

Formulation of fast dissolving oral film of cetirizine hydrochloride by solvent casting method: in vitro study

Article in Press

The objective of the study was to design a fast-dissolving film of cetirizine hydrochloride (CTZHCl) by the solvent casting method using various film-forming polymers like Hydroxyl propyl methylcellulose (HPMC K4M), Polyvinyl alcohol (PVA), Sodium alginate (Na-alg). Six different formulations were designed by varying the concentration of film-forming polymer. Acquired formulations were subjected to various physicochemical,...

Author(s):Chhitij Thapa

Comparative analysis of Phytochemical Constituents and Antioxidant activity of two Pomegranate (Punica granatum L.) cultivars

Article in Press

Pomegranate (Punica granatum L.) is a well-known and widely used fruit, which contains several interesting bioactive compounds and possess health-promoting properties. Seeing the importance of this fruit, it was essential to study its quality characteristics. Hence, in the current study, we assessed total phenolic content, flavonoid content and antioxidant activity of different plant parts (leaves, rind and arils) of two...

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Treatment outcome and associated factors among adult epileptic patients at Hawassa University Specialized Hospital, Southern Ethiopia

Article in Press

Epilepsy, once thought to be a disease of evil spirit, is now believed by many as a common neurologic condition that can be effectively treated by optimal use of anti seizure drugs. Despite the availability of multiple and cost effective medications, people with epilepsy could experience episodes of seizures. Aim of the present study was to assess the treatment outcome and associated factors among adult epileptic patients...

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Antioxidant, Cytotoxicity, Embryotoxicity and Teratogenic Effects of Some Malaysian Medicinal Plants on SH-SY5Y cells and Zebrafish Embryos Model

Article in Press

Some Malaysian plants were extracted using 80% methanol and screened for antioxidant and toxicity effects on human neuroblastomacells line (SH-SY5Y cells) and zebrafish(Daniorerio) embryos. Antioxidant assay shows high activities with of IC50 1–100 µg/mL with Melastoma malabathricum (leaf and stem), Murraya koenigii (leaf), Curcuma longa (leaf and rhizome), Ficus deltoidea (leaf), Phaleria macrocarpa (leaf) and Ginkgo...

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1. Quality Assessment of Analgesics Paracetamol (500 Mg) and Ibuprofen (400 Mg) for Sale in the City of Douala in Cameroon: Central Marche Case And Ndokoti.

Article in Press

Base on the findings from the Research Institute Against Counterfeit drugs (RIACD) and the Organization for Economic Cooperation and Development Drugs (OECD), 700,000 cases of death are recorded per year due to malaria and tuberculosis counterfeit drugs. According to the World Health Organization (WHO), roadside drugs kill at least 100,000 people in Africa every year, 1/3 of these drugs are counterfeit. The objective of...

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Determination of radical scavenging activities of Acorus calamus,Prunus persica and Sassurea lappa extracts

Article in Press

Antioxidants from plants origin are considered as a promising source of biologically active substances when compared to synthetic agents who are accompanied with a number of side effects. Three botanical extracts of Acorus calamus (sweet flag), Prunus persica (peach) and Sausskurea lappa (kuth) were characterized for their antioxidant properties. Methanolic extract was prepared and concentrated by rotary evaporated. The...

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The effects of process variables on physicochemical properties and in-vitro cytotoxic activities of 5-Fluorouracilnanoparticlesagainst Squamous cell carcinoma (SCC)

Article in Press

A 23 factorial experimental design was used to study the effects of polymer type (A), the nature of the organic phase (B) and the homogenization speed (C) on the particle sizes (S), the amount of drug entrapped (E) and the in-vitro release properties of the formulations (R). Objective This study was aimed to quantify the effects of three production variables on the physicochemical and cytotoxic activities of...

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FORMULATION, OPTIMIZATION AND CHARACTERIZATION OF NANOCRYSTALS OF AN ANTIBIOTIC

Article in Press

Nitrofurantoin is a broad-spectrum bactericidal antibiotic which affect both Gram-negative and Gram-positive bacteria. Nitrofurantoin exhibits bacteriostatic or bactericidal effects by inhibiting the synthesis of DNA, RNA, protein and cell wall synthesis. Nanocrystals of NFT were prepared by Cold High Pressure Homogenization technique. NFT was dispersed in aqueous surfactant solution containing Poloxamer 188, PVPK 30 and...

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