African Journal of
Pharmacy and Pharmacology

  • Abbreviation: Afr. J. Pharm. Pharmacol.
  • Language: English
  • ISSN: 1996-0816
  • DOI: 10.5897/AJPP
  • Start Year: 2007
  • Published Articles: 2145

Table of Content: 15 March, 2012; 6(10)

March 2012

Extensive studies on polymerase chain reaction-sequence-specific primers (PCR-SSP) based HLA-DRB1* allele profiling in non insulin dependent diabetes mellitus (Indian population)

Human leukocyte antigen (HLA) system, the most polymorphic and comprehensively studied gene locus, is extensively used to understand the evolution of genetic relatedness and migration of different world populations. To analyze the contribution of HLA class II genes in type 2 diabetes mellitus, we examined the distribution of HLA- DRB1* loci in Indian population of Tamil Nadu using polymerase chain...

Author(s): P. Prabhavathi, K. Balakrishnan, V. Prabakaran, R. Rajendran and T. Kuberan

March 2012

Functional IL-18 promoter gene polymorphisms and haplotypes in patients with lichen planus: A study in a Chinese population

The aim of this study was to evaluate the association of single nucleotide polymorphisms (SNPs) in the IL-18 promoter gene, which regulates IL-18 gene expression in the patients with lichen planus (LP) in Chinese. Two SNPs of the IL-18 promoter gene at positions -607C/A and -173G/C were analyzed in 79 patients with LP and 85 controls by using polymerase chain reaction-restriction fragment length polymorphism (PCR-RFLP)...

Author(s): Fang Liu and Wenwen Fu

March 2012

Chemical composition of n-butanol extract of Potentilla anserina L. and its protective effect of EAhy926 endothelial cells under hypoxia

The protective role of n-butanol extract of Potentilla anserina roots was measured by 3-(4, 5-dimethylthiazol-2yl)-2, 5-diphenyl tetrazolium bromide (MTT) method and colorimetric method on human umbilical vein endothelial cells (EAhy926) under hypoxia injury. The extract tested (3 and 1.5 mg/ml) remarkably increased cell viability, the activity of superoxide dismutase (SOD) and the concentration of...

Author(s): D. L. Liu, S. Wang, L. Zhang and L. Z. Li,

March 2012

Effect of thespesone-vanadium complex in alloxan induced diabetic rats

In the present study, we isolated “thespesone”, a pyranonapthaquinone, from Thespesia populnea, complexed with vanadium (TVa) evaluated for diabetes mellitus in alloxan induced diabetic rats. Diabetes was induced by pre-standardized dose of alloxon in the animals. Diabetic animals showed significant increase (p < 0.01) in the levels of plasma glucose, serum triglycride, cholesterol, and blood...

Author(s): Phanse Mohini, Padhye Subhash, Patil Manohar, Takawale Abhijit and Navghare Vijay

March 2012

Evaluation of Viola betonicifolia for anthelmintic activity

In the present study, crude methanolic extract and its subsequent solvent fractions of Viola betonicifolia were tested against the adult species Pheretima posthuma and Juvenile species (Cephalobus litoralis and Helicotylenchus indicus) of worms. The anthelmintic activity of ethyl acetate and chloroform fractions was very significant against P. posthuma, in a concentration...

Author(s): Naveed Muhammad, Muhammad Saeed, Haroon Khan, Mughal Qayum, Barkatullah and Amir Badshah

March 2012

Prokinetic effects of ghrelin in streptozotocin-induced diabetic guinea pigs

The aim of this paper is to investigate the effects of ghrelin on delayed gastrointestinal transit in streptozotocin-induced diabetic guinea pigs. A diabetic guinea pig model was produced by intraperitoneal (i. p.) injection of streptozotocin (STZ, 280 mg/kg). Diabetic guinea pigs were randomized into two main groups: normal guinea pigs and ghrelin-treated diabetic guinea pigs with doses of 0, 10, 20, 50 and 100...

Author(s): Wen-Cai Qiu, Cheng-Guang Yang, Jun Yan, Zhi-Gang Wang, Qi Zheng

March 2012

A sensitive, fast and accurate liquid chromatography–electrospray ionization-tandem mass spectrometry (LC–MS/MS) method for the pharmacokinetic study of cyclobenzaprine tablets

A simple, fast and accurate liquid chromatography–electrospray ionization-tandem mass spectrometry method was developed and validated for the quantification of cyclobenzaprine in human plasma. After a simple single-step liquid–liquid extraction with ethyl acetate, the analyte was separated in an Intersil ODS-3 column through isocratic elution with methanol–water containing 0.1% formic acid (80:20, v/v)...

Author(s): Jian-Chun Li, Fei-Hu Chen, Jun-Dong Zhang, Hai-Jun Dong and Shu Gao

March 2012

Tobacco smoking vs. lipid profile and anthropometric measures: A cross-sectional study among students in the Riyadh College of Health Sciences

Smoking represents the most readily preventable risk factor for morbidity and mortality. The present work aimed at studying the frequency of smoking among Saudi college students and its relation to dyslipidemia and malnutrition. The study was carried out on the students of the Riyadh College of Health Sciences, from September 2006 to December 2008. 474 male students participated in the present study. All subjects...

Author(s): Abdul Rahman Al-Ajlan

March 2012

Antimicrobial potency of the ethanolic crude bark extract of Ziziphus mucronata Willd. subsp. mucronata Willd.

Ziziphus mucronata Willd. subsp. mucronata Willd. is a medicinal plant widely used in South Africa for the treatment of various diseases. Like many medicinal plants to which traditional claims including the treatment of ailments of infectious origin but without scientific reports have been associated, Z. mucronata is not an exemption. The ethanolic stems bark extract ofZ. mucronata against...

Author(s): O. O. Olajuyigbe and A. J. Afolayan

March 2012

Analysis of false positive positron emission tomography with 2-fluoro (18-F)-2-deoxy-D glucose as a tracer in patients with suspected lung cancer

Accurate diagnosis of lung cancer is a critical factor determining operability in patients with non-small cell lung cancer (NSCLC). Positron emission tomography with 2-fluoro (18F)- 2-deoxy-D glucose as a tracer (FDG-PET) has been reported to be effective in detecting tumor and involvement in mediastinal and hilar lymph nodes. In this study, we analyzed the accuracy of FDG-PET in pulmonary lesions which were suspected...

Author(s): Servet Kayhan, Nesimi Günal and Hikmet Tereci

March 2012

Inhibitory effect of resveratrol on advanced glycation end products-induced mesangial cell proliferation

Diabetic nephropathy (DN) is the major cause of end-stage renal disease. An important histological hallmark of DN is proliferation of mesangial cells, and as a result, the expansion of extracellular matrix in the mesangium. Resveratrol has been shown to ameliorate hyperglycemia in diabetic rats. However, the effects of resveratrol on DN remain unknown. The aim of the present study is to investigate the effects of...

Author(s): Bei Jiang, Baoying Li, Ling Guo, Jian Song, Xianhua Li, Xiangdong Yang, Zhao Huand Haiqing Gao

March 2012

Antioxidant activities in vitro and hepatoprotective effects of Lysimachia clethroides Duby on CCl4-induced acute liver injury in mice

The antioxidant activity of the extracts of Lysimachia clethroides Duby (LC) was assayed by the methods of 2,2-diphenyl-1-picrylhydrazyl (DPPH) and 2,2-azino-bis(3-ethylbenzo-thiazoline-6-sulfonicacid) (ABTS) in vitro. The ethyl acetate (LCEA) and n-butanol extracts (LCBU) of L. clethroides were the higher antioxidant activity in DPPH and ABTS assay. LCEA had the highest antioxidant...

Author(s): Jin-feng Wei,, Yuan-yuan Li, Zhen-hua Yin, Fang Gong and Fu-de Shang

March 2012

Antiulcerogenic activity of Apium graveolens seeds oils isolated by supercritical CO2

Isolation of volatile and fixed oils from Apium graveolens seeds have been obtained by supercritical fluid extraction (SFE) with carbon dioxide. The first extraction step (90 bar, 40°C) produced a volatile fraction (yield of 1.5% by weight of the charge) mainly formed by sedanolide, neocnidilide, b-selinene and 3-buthyl phtalide. The second extraction step (250 bar, 40°C) produced a fixed oil and...

Author(s): Sameh Baananou, Alessandra Piras, Bruno Marongiu, M. Assunta Dessì, Danilo Falconieri, Silvia Porcedda, Antonella Rosa, Naceur A. Boughattas

March 2012

A cross-sectional study on knowledge, attitude and behavior related to antibiotic use and resistance among medical and non-medical university students in Jordan

Irrational antibiotics use is a major reason for the spread of antibiotic resistance. Earlier studies from Jordan indicated irrational antibiotic use among the public. Our aim is to evaluate the current knowledge, attitude and behaviour regarding antibiotic use and reasons for resistance development among university students in Jordan. A cross-sectional, questionnaire-based survey involving medical and non-medical...

Author(s): Ghadeer A. R. Y. Suaifan, Mayada Shehadeh, Dana A. Darwish, Hebah Al-Ije, Al-Motassem M. Yousef and Rula M. Darwish

March 2012

Antiprotozoal effect of Allium cepa on acute renal failure caused by Toxoplasma gondii

Renal failure is described as a decrease in glomerular filtration rate. Biochemically, renal failure is typically detected by an elevated serum creatinine level. The present study was investigated to evaluate the effects of Allium cepa on renal failure in male rats which experimentally infected by Toxoplasma gondii, RH strain. Wistar male rats (n=40) were allocated into four...

Author(s): Yaghub Gharadaghi, Saeedeh Shojaee, Arash Khaki, Fatemeh fathiazad, Amir afshin Khaki, Elham Ghdamkheir and Mahdi rouhaninia