October 2017

A review of clinical pharmacokinetics of chloroquine and primaquine and their application in malaria treatment in Thai population

The blood schizontocidal chloroquine (CQ) and the tissue schizontocidal and gametocytocidal primaquine (PQ) remain the mainstay treatment of Plasmodium vivax and Plasmodium ovale infections for more than six decades. The review focuses on the clinical pharmacokinetic studies of both drugs in Thai population that have provided useful information for clinical application in the treatment of malaria.  There appears to...

Author(s): Kodchakorn Chukanchitipat and Kesara Na-Bangchang

October 2017

Production of gastro-resistant coated tablets prepared from the hydroethanolic standardized roots extract of Harpagophytum procumbens DC.

This project aimed at developing a gastro-resistant coated tablet using traditional herbal medicine dry extract from the secondary roots of the plant species Harpagophytum procumbens DC. (Pedaliaceae), standardized in harpagoside 20%, popularly known as "devil's claw". The tablets were produced by direct compression and coated with the gastro-resistant dispersion. Accelerated and long-term stability...

Author(s): Andrey Pereira Lopes, Bianca Souza Bagatela, Ivan Pereira Lopes, Luiz Elidio Gregório, Edson Luis Maistro, Fernando Luiz Affonso Fonseca, and Fábio Ferreira Perazzo,