African Journal of
Pharmacy and Pharmacology

  • Abbreviation: Afr. J. Pharm. Pharmacol.
  • Language: English
  • ISSN: 1996-0816
  • DOI: 10.5897/AJPP
  • Start Year: 2007
  • Published Articles: 2205

Table of Content: 15 September, 2016; 10(34)

September 2016

Ameliorative effect of grape seed extract on metabolic disorders caused by high fat diet induced obesity in rats by reversing the increase in hepatic miR-33a and miR-122

MiR-33a and miR-122 are major regulators of lipid metabolism in the liver and their deregulation has been linked to the development of metabolic diseases such as obesity and metabolic syndrome. The aim of this study was to evaluate whether the level of miR-33a and miR-122 in rat liver correlate with obesity and potential anti-obesity effect of grape seed extract (GSE) and calorie restricted diet with special emphasis on...

Author(s): Hoda E. Mohamed, Dina M. Abo-ELmatty, Same M Saleh and Amr T. Sakr

September 2016

Toxicological assessment of the aqueous dried leaf extracts of Senna alata L. in wistar rats

Senna alata is a medicinal plant that belongs to Leguminosae family. Different parts of the plant are used in folklore medicine for curing skin infections, abdominal pain, and gonorrhoea. Despite the use of S. alata in the treatment of various ailments, there is limited or no comprehensive scientific information on the toxicological evaluation of the dried leaf extract in the folklore medicine in Africa. This study...

Author(s): Eziuche Amadike Ugbogu, Emmanuel Okezie, Iheanyichukwu Elekwa, Friday Uhegbu, Emmanuel Akubugwo, Chinyere Godwin Chinyere, Faith Ewuzie and Chizoba Jennifer Ugorji

September 2016

In vitro and in vivo assessment of genotoxic activity of Petiveria alliacea

Petiveria alliacea L. (Phytolaccaceae) is an Amazonian shrub used in traditional medicine for many purposes. This study investigated the genotoxicity of the hydroalcoholic extract of P. alliacea (EHPa). In addition, we conducted pharmacognostic characterization and phytochemical investigation. Phytochemical screening and thin layer chromatography (TLC) were used to determine the chemical composition of the extract....

Author(s): João Paulo Bastos Silva, Fábio Rodrigues de Oliveira, Thiago Portal da Paixão, Nívea Silva Malcher, Patrícia Carara dos Santos, Ana Cristina Baetas, Maria do Carmo Pimentel Batitucci, Marta Chagas Monteiro, and Marcieni Ataíde de Andrade,